Clinical characteristics and laboratory findings of 252 Chinese patients with anti-phospholipid syndrome: comparison with Euro-Phospholipid cohort
Clinical characteristics and laboratory findings of 252 Chinese patients with anti-phospholipid syndrome: comparison with Euro-Phospholipid cohort
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252例中国抗磷脂综合征患者的临床特征和实验室检查结果：与欧洲磷脂队列的比较
DOI：
10.1007/s10067-017-3549-1
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发表时间：
2017-01
影响因子：
3.4
通讯作者：
Yang Cheng-de
中科院分区：
文献类型：
--
作者：
Shi Hui;Teng Jia-lin;Sun Yue;Wu Xin-yao;Hu Qiong-yi;Liu Hong-lei;Cheng Xiao-bing;Yin Yu-feng;Ye Jun-na;Chen Pojen P.;Yang Cheng-de
本研究旨在描述中国汉族抗磷脂综合征（APS）患者的特征，并与欧洲-磷脂队列的数据进行比较。我们在2000年至2015年进行了一项由252名确诊APS患者组成的单中心研究。我们分析了我们队列的临床和实验室特征，并将数据与欧洲磷脂队列的数据进行了比较。我们的队列包括216名女性和36名男性，入组时的平均年龄为41岁（范围11-74岁）。其中69例（27.4%）为原发性APS， 183例（72.6%）为继发性APS，其中163例（64.7%）为系统性红斑狼疮（SLE）。190例（75.4%）患者发生血栓形成事件，其中最常见的是深静脉血栓形成（40.1%）和脑卒中（23.8%），这与euro -磷脂队列的报道相似。相比之下，我们的队列肺栓塞较少（6.7%）。在93例299次妊娠中，早期（<10周）和晚期（≥10周）流产率分别为37.8%和24.4%。后者显著高于欧洲-磷脂组。此外，在我们的队列中发现了7例APS肾病患者（以血栓性微血管病变为组织病理学特征）和8例灾难性APS患者。169例（67.1%）检测到抗心磷脂抗体（aCL）， 83例（32.9%）检测到狼疮抗凝血剂（LA）， 148例（58.7%）检测到抗β2糖蛋白I抗体（anti-β2GPI）。这些结果表明，APS的一些临床表现可能在不同的种族群体中有所不同。
This study aims to characterize the Chinese Han patients with anti-phospholipid syndrome (APS) and compare the data with those of the Euro-Phospholipid cohort. We conducted a single center study consisting of 252 patients with definite APS from 2000 to 2015. We analyzed the clinical and laboratory characteristics of our cohort and compared the data with those of the Euro-Phospholipid cohort. Our cohort consisted of 216 females and 36 males, with a mean age at entry into this study of 41 years (range 11–74 years). Of these patients, 69 (27.4%) patients had primary APS, and 183 (72.6%) had secondary APS (SAPS), including 163 (64.7%) patients had systemic lupus erythematosus (SLE). Thrombotic events occurred in 190 (75.4%) patients, and the most common ones were deep vein thrombosis (40.1%) and stroke (23.8%), which were similar to the reports of the Euro-Phospholipid cohort. In contrast, our cohort had less pulmonary embolism (6.7%). Among 93 females with 299 pregnancy episodes, the rates of early (<10 weeks) and late fetal loss (≥10 weeks) were, respectively, 37.8% and 24.4%. The latter was significantly higher than that of the Euro-Phospholipid cohort. Moreover, 7 APS nephropathy patients (characterized histopathologically by thrombotic microangiopathy) and 8 catastrophic APS patients were found in our cohort. Anti-cardiolipin antibodies (aCL) were detected in 169 (67.1%) patients, lupus anti-coagulant (LA) was detected in 83 (32.9%), and anti-β2 glycoprotein I antibodies (anti-β2GPI) in 148 (58.7%) patients. These results show that some clinical manifestations of APS may vary among different racial groups.
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DOI：
--
发表时间：
2008-10
期刊：
The Journal of rheumatology
影响因子：
--
作者：
M. Tektonidou;F. Sotsiou;H. Moutsopoulos
通讯作者：
M. Tektonidou;F. Sotsiou;H. Moutsopoulos
影响因子：
6.3
作者：
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通讯作者：
Kelly-Hayes M
影响因子：
4
作者：
Kolte, A. M.;Nielsen, H. S.;Christiansen, O. B.
通讯作者：
Christiansen, O. B.
影响因子：
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作者：
MCCARTY, DJ;MANZI, S;KWOH, CK
通讯作者：
KWOH, CK
影响因子：
2.9
作者：
Li Wang;Zeng Chan Wang;Cui Xie;Xiao Feng Liu;Mao Sheng Yang
通讯作者：
Li Wang;Zeng Chan Wang;Cui Xie;Xiao Feng Liu;Mao Sheng Yang