Analytical processing of binary mixture information by olfactory bulb glomeruli.
Analytical processing of binary mixture information by olfactory bulb glomeruli.
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DOI：
10.1371/journal.pone.0029360
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Fletcher ML
中科院分区：
文献类型：
--
作者：
Fletcher ML
气味很少由单一化合物组成，而是包含大量复杂的化学成分。通常，这些混合物被认为具有独特的品质，可能与它们的成分组合完全不同。在许多情况下，混合物的大部分成分不能单独识别。这种对气味信息的合成处理表明，混合物的各个成分表征必须在嗅觉通路的某个地方相互作用。感觉神经元与球一起输入分离肾小球的解剖性质表明，气味信息的初始输入是分析性的。然而，嗅球内的大型中间神经元网络可以通过侧向抑制等机制允许混合相互作用。目前在哺乳动物中，尚不清楚突触后二尖瓣/簇状细胞肾小球混合反应是否反映了分析混合输入，还是为嗅觉系统的合成加工提供了初始基础。为了解决这个问题，利用在嗅球二尖瓣/簇状细胞中表达钙指示剂G-CaMP2的转基因小鼠，将嗅球肾小球二元混合物的表征与每种成分的表征进行了比较。总的来说，背表面混合表征显示出很少的混合相互作用，通常表现为组成表征的简单组合。基于此，得出的结论是，背表面肾小球混合物的表征在很大程度上仍然是分析性的，几乎保留了所有成分信息。
Odors are rarely composed of a single compound, but rather contain a large and complex variety of chemical components. Often, these mixtures are perceived as having unique qualities that can be quite different than the combination of their components. In many cases, a majority of the components of a mixture cannot be individually identified. This synthetic processing of odor information suggests that individual component representations of the mixture must interact somewhere along the olfactory pathway. The anatomical nature of sensory neuron input into segregated glomeruli with the bulb suggests that initial input of odor information into the bulb is analytic. However, a large network of interneurons within the olfactory bulb could allow for mixture interactions via mechanisms such as lateral inhibition. Currently in mammals, it is unclear if postsynaptic mitral/tufted cell glomerular mixture responses reflect the analytical mixture input, or provide the initial basis for synthetic processing with the olfactory system. To address this, olfactory bulb glomerular binary mixture representations were compared to representations of each component using transgenic mice expressing the calcium indicator G-CaMP2 in olfactory bulb mitral/tufted cells. Overall, dorsal surface mixture representations showed little mixture interaction and often appeared as a simple combination of the component representations. Based on this, it is concluded that dorsal surface glomerular mixture representations remain largely analytical with nearly all component information preserved.
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影响因子：
25
作者：
Barnes, Dylan C.;Hofacer, Rylon D.;Zaman, Ashiq R.;Rennaker, Robert L.;Wilson, Donald A.
通讯作者：
Wilson, Donald A.
影响因子：
5.3
作者：
RALL, W;SHEPHERD, GM;BRIGHTMAN, MW
通讯作者：
BRIGHTMAN, MW
影响因子：
2.5
作者：
Fletcher, Max L.;Masurkar, Arjun V.;Chen, Wei R.
通讯作者：
Chen, Wei R.
影响因子：
16.2
作者：
Lin, Da Yu;Shea, Stephen D.;Katz, Lawrence C.
通讯作者：
Katz, Lawrence C.
DOI：
10.1002/cne.22289
发表时间：
2010-05-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Johnson BA;Ong J;Leon M
通讯作者：
Leon M