Glomerular activity patterns evoked by natural odor objects in the rat olfactory bulb are related to patterns evoked by major odorant components.
Glomerular activity patterns evoked by natural odor objects in the rat olfactory bulb are related to patterns evoked by major odorant components.
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DOI：
10.1002/cne.22289
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发表时间：
2010-05-01
期刊：
影响因子：
--
通讯作者：
Leon M
中科院分区：
文献类型：
--
作者：
Johnson BA;Ong J;Leon M
为了确定由天然气味混合物引起的反应与单个气味化学物质引起的反应相比如何，我们绘制了暴露于各种气味物体产生的蒸汽期间2-脱氧葡萄糖摄取的图，这些气味物体可能对野生啮齿动物很重要。我们研究了21种不同的自然气味刺激，从可能的食物来源，如水果、蔬菜和肉类到环境气味物体，如草、草药和树叶。自然气味诱发了2-脱氧葡萄糖摄取的强大和令人惊讶的局灶模式，涉及邻近的肾小球簇，因此类似于纯化学物质引起的模式。总的来说，这些模式与之前研究过的单分子气味成分引起的模式显著相关。物体图案也与混合物组分中存在的分子特征显著相关。尽管有这些整体的关系，但考虑到蒸汽中存在的成分的多样性，物体模式的个别例子可能比预测的要简单。在这些情况下，物体模式缺乏由其主要气味混合成分引起的某些反应。这些数据提示了混合反应相互作用的可能性，并为理解自然气味刺激的神经编码提供了基础。
To determine how responses evoked by natural odorant mixtures compare to responses evoked by individual odorant chemicals, we mapped 2-deoxyglucose uptake during exposures to vapors arising from a variety of odor objects that may be important to rodents in the wild. We studied 21 distinct natural odor stimuli ranging from possible food sources such as fruits, vegetables, and meats to environmental odor objects such as grass, herbs, and tree leaves. The natural odor objects evoked robust and surprisingly focal patterns of 2-deoxyglucose uptake involving clusters of neighboring glomeruli, thereby resembling patterns evoked by pure chemicals. Overall, the patterns were significantly related to patterns evoked by monomolecular odorant components that had been studied previously. Object patterns also were significantly related to the molecular features present in the mixture components. Despite these overall relationships, there were individual examples of object patterns that were simpler than might have been predicted given the multiplicity of components present in the vapors. In these cases, the object patterns lacked certain responses evoked by their major odorant mixture components. These data suggest the possibility of mixture response interactions and provide a foundation for understanding the neural coding of natural odor stimuli.
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在大鼠和小鼠的嗅球中，气味的空间表示：趋化组织中的相似性和差异。
DOI：
10.1002/cne.22046
发表时间：
2009-06-20
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Johnson BA;Xu Z;Ali SS;Leon M
通讯作者：
Leon M
影响因子：
16.2
作者：
Abraham, NM;Spors, H;Schaefer, AT
通讯作者：
Schaefer, AT
影响因子：
2.5
作者：
Johnson, BA;Ho, SL;Leon, M
通讯作者：
Leon, M
影响因子：
6.1
作者：
BUCKHOLZ, LL;WITHYCOMBE, DA;DAUN, H
通讯作者：
DAUN, H
影响因子：
2.9
作者：
Derby, CD
通讯作者：
Derby, CD