The Effect of Gender-Affirming Medical Care on the Vaginal and Neovaginal Microbiomes of Transgender and Gender-Diverse People.
The Effect of Gender-Affirming Medical Care on the Vaginal and Neovaginal Microbiomes of Transgender and Gender-Diverse People.
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DOI：
10.3389/fcimb.2021.769950
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发表时间：
2021
影响因子：
5.7
通讯作者：
Prodger JL
中科院分区：
文献类型：
--
作者：
Krakowsky Y;Potter E;Hallarn J;Monari B;Wilcox H;Bauer G;Ravel J;Prodger JL
变性人和性别多样化的个人可能会寻求性别肯定的医疗护理，如激素治疗或手术，以产生与其性别更一致的主要和/或次要性特征。跨性别个体的性别确认医疗护理可包括睾酮治疗，其抑制循环雌激素并可导致阴道上皮的变化，这让人想起顺性别女性的绝经后时期。在跨女性个体中，性别确认的医疗护理可以包括阴道成形术，这是一种外阴和新阴道腔的外科手术，通常使用阴茎和阴囊皮肤。确认性别的医疗护理对跨男性个体的阴道和跨女性个体的新生阴道的影响特征不明显。本文综述了睾丸激素暴露的阴道和新生阴道的上皮细胞和局部微生物群。我们专注于妇科健康的潜在病原体和决定因素，并确定未来研究的关键知识差距。
Transgender and gender diverse individuals may seek gender-affirming medical care, such as hormone therapy or surgery, to produce primary and/or secondary sex characteristics that are more congruent with their gender. Gender-affirming medical care for transmasculine individuals can include testosterone therapy, which suppresses circulating estrogen and can lead to changes in the vaginal epithelium that are reminiscent of the post-menopausal period in cisgender females. Among transfeminine individuals, gender-affirming medical care can include vaginoplasty, which is the surgical creation of a vulva and neovaginal canal, commonly using penile and scrotal skin. The effect of gender-affirming medical care on the vagina of transmasculine individuals and on the neovagina of transfeminine individuals is poorly characterized. This review summarizes what is known of the epithelium and local microbiota of the testosterone-exposed vagina and the neovagina. We focus on potential pathogens and determinants of gynecological health and identify key knowledge gaps for future research.
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DOI：
10.1086/657320
发表时间：
2010-12-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Brotman RM;Klebanoff MA;Nansel TR;Yu KF;Andrews WW;Zhang J;Schwebke JR
通讯作者：
Schwebke JR
影响因子：
3.7
作者：
Dinh MH;Hirbod T;Kigozi G;Okocha EA;Cianci GC;Kong X;Prodger JL;Broliden K;Kaul R;Serwadda D;Wawer MJ;Gray RH;Hope TJ
通讯作者：
Hope TJ
影响因子：
2.6
作者：
Dy, Geolani W.;Sun, Jeff;Zhao, Lee C.
通讯作者：
Zhao, Lee C.
影响因子：
3.1
作者：
BODSWORTH, NJ;PRICE, R;DAVIES, SC
通讯作者：
DAVIES, SC
影响因子：
--
作者：
Carias, Ann M.;Hope, Thomas J.
通讯作者：
Hope, Thomas J.