Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices.
Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices.
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DOI：
10.1016/j.brs.2011.10.001
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发表时间：
2012-10
影响因子：
7.7
通讯作者：
Bikson, Marom
中科院分区：
文献类型：
--
作者：
Peterchev, Angel V.;Wagner, Timothy A.;Miranda, Pedro C.;Nitsche, Michael A.;Paulus, Walter;Lisanby, Sarah H.;Pascual-Leone, Alvaro;Bikson, Marom
在基础研究和临床应用中越来越多地使用经颅电和磁（EM）脑刺激，需要清楚地了解什么是EM刺激的剂量以及应该如何报告。电磁刺激的生物效应是通过在体内注入（通过电刺激）或诱导（通过磁刺激）的电磁场来介导的。因此，经颅电磁刺激剂量应该由影响体内产生电磁场的刺激装置的所有参数来定义，包括刺激电极或线圈的配置参数：形状、大小、位置、电性能，以及电极或线圈的电流（或电压）波形参数：脉冲形状、幅度、宽度、极性、重复频率；脉冲或脉冲序列之间的持续时间和间隔；脉冲总数；刺激次数和总次数之间的间隔。了解体内产生的电磁场可能是不够的，但对于了解电磁刺激的生物效应是必要的。我们认为，电刺激剂量的报告应遵循可重复性原则：应提供有关刺激参数的充分信息，以便剂量可以重复。本文提供了包括任何经颅电脑刺激方案的剂量报告的基本定义和原则。
The growing use of transcranial electric and magnetic (EM) brain stimulation in basic research and in clinical applications necessitates a clear understanding of what constitutes the dose of EM stimulation and how it should be reported. The biological effects of EM stimulation are mediated through an electromagnetic field injected (via electric stimulation) or induced (via magnetic stimulation) in the body. Therefore, transcranial EM stimulation dose ought to be defined by all parameters of the stimulation device that affect the electromagnetic field generated in the body, including the stimulation electrode or coil configuration parameters: shape, size, position, and electrical properties, as well as the electrode or coil current (or voltage) waveform parameters: pulse shape, amplitude, width, polarity, and repetition frequency; duration of and interval between bursts or trains of pulses; total number of pulses; and interval between stimulation sessions and total number of sessions. Knowledge of the electromagnetic field generated in the body may not be sufficient but is necessary to understand the biological effects of EM stimulation. We believe that reporting of EM stimulation dose should be guided by the principle of reproducibility: sufficient information about the stimulation parameters should be provided so that the dose can be replicated. This paper provides fundamental definition and principles for reporting of dose that encompass any transcranial EM brain stimulation protocol.
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