JC virus: an oncogenic virus in animals and humans?
JC virus: an oncogenic virus in animals and humans?
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DOI：
10.1016/j.semcancer.2009.02.013
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发表时间：
2009-08
影响因子：
14.5
通讯作者：
Atwood WJ
中科院分区：
文献类型：
--
作者：
Maginnis MS;Atwood WJ
JCV是多瘤病毒科的人多瘤病毒，其还包括BK病毒和猿猴空泡病毒40（SV40）。JC病毒（JCV）于1971年首次从患有进行性多灶性白质脑病（PML）的患者的脑中分离。与其他多瘤病毒一样，JCV具有有限的宿主范围。该病毒感染大多数人，在青春期发生血清转化。JCV具有有限和特异性的组织嗜性，感染肾脏和中枢神经系统（CNS）中的少突胶质细胞和星形胶质细胞。初始JCV感染在免疫活性宿主中通常无症状，并且它在肾脏和可能的骨髓中建立持续感染。在免疫功能低下的个体中，JCV可引起CNS溶解性感染，并导致致命性脱髓鞘疾病PML的发展。多瘤病毒的名称来源于希腊语：poly，意思是许多，oma，意思是肿瘤，这是由于这组病毒引起肿瘤的能力。小动物模型和非人灵长类动物的JCV接种（其不允许生产性JCV感染）导致肿瘤形成。鉴于该病毒无处不在的性质及其在动物模型中与癌症的密切联系，假设JCV在人类癌症中发挥作用。然而，JCV在人类癌症和肿瘤形成中的作用尚不清楚。一些研究人员报告了JCV与人类癌症的相关性，包括脑肿瘤，结直肠癌和胃肠道癌症，而其他研究小组报告没有相关性。在这里，我们回顾了JCV在动物模型癌症中的作用，并介绍了JCV在人类癌症中的发现。
JCV is a human polyomavirus of the Polyomaviridae family, which also includes BK virus and simian vacuolating virus 40 (SV40). JC virus (JCV) was first isolated in 1971 from the brain of a patient with Progressive Multifocal Leukoencephalopathy (PML). Like other polyomaviruses, JCV has a restricted host range. The virus infects the majority of the human population with seroconversion occurring during adolescence. JCV has a limited and specific tissue tropism infecting the kidney and oligodendrocytes and astrocytes in the central nervous system (CNS). Initial JCV infection is generally asymptomatic in immunocompetent hosts, and it establishes a persistent infection in the kidney and possibly bone marrow. In immunocompromised individuals JCV can cause a lytic infection in the CNS and lead to development of the fatal, demyelinating disease PML. The name polyoma is derived from the Greek terms: poly, meaning many, and oma, meaning tumors, owing to the capacity of this group of viruses to cause tumors. JCV inoculation of small animal models and non-human primates, which are not permissive to a productive JCV infection, leads to tumor formation. Given the ubiquitous nature of the virus and its strong association with cancer in animal models, it is hypothesized that JCV plays a role in human cancers. However, the role for JCV in human cancers and tumor formation is not clear. Some researchers have reported an association of JCV with human cancers including brain tumors, colorectal cancers, and cancers of the gastrointestinal tract, while other groups report no correlation. Here, we review the role of JCV in cancers in animal models and present the findings on JCV in human cancers.
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影响因子：
5.4
作者：
BOLLAG, B;CHUKE, WF;FRISQUE, RJ
通讯作者：
FRISQUE, RJ
DOI：
10.1136/mp.54.5.331
发表时间：
2001-10-01
期刊：
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
影响因子：
--
作者：
Del Valle, L;Baehring, J;Croul, S
通讯作者：
Croul, S
影响因子：
3.2
作者：
Dörries, K;Sbiera, S;Dörries, R
通讯作者：
Dörries, R
影响因子：
4.4
作者：
Bofill-Mas, S;Pina, S;Girones, R
通讯作者：
Girones, R
影响因子：
11.4
作者：
Chen, XJS;Stehle, T;Harrison, SC
通讯作者：
Harrison, SC