Smoking and Lung Cancer: A Geo-Regional Perspective.
Smoking and Lung Cancer: A Geo-Regional Perspective.
复制标题
DOI：
10.3389/fonc.2017.00194
复制
发表时间：
2017
影响因子：
4.7
通讯作者：
Kadara H
中科院分区：
文献类型：
--
作者：
Rahal Z;El Nemr S;Sinjab A;Chami H;Tfayli A;Kadara H
肺癌是全球癌症相关死亡的主要原因。非小细胞肺癌（NSCLC）是最常见的诊断亚型。NSCLC与烟草消费有因果关系，全球有超过5亿吸烟者处于这种致命恶性肿瘤的高风险中。我们目前对早期分子（例如，吸烟在NSCLC发病机制中的作用，这将构成早期检测的理想标志物。当考虑到地球仪不同地区NSCLC发病机制的不同病因因素时，这种局限性进一步扩大。在这篇综述中，我们提出了我们目前的知识，在吸烟诱导的肺癌的发生和发展的早期阶段，包括讨论吸烟引起的损伤的癌前气道领域的基因组改变。审查还强调了烟草的更广泛的范围和更高的年龄调整率（例如，沿着较高的环境致癌物暴露和相对较差的社会经济地位，以黎巴嫩为例。这种致癌物质暴露的“鸡尾酒”保证迫切需要了解在LMIC（如黎巴嫩）发生的肺恶性肿瘤的复杂病因。
Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) represents the most frequently diagnosed subtype of this morbid malignancy. NSCLC is causally linked to tobacco consumption with more than 500 million smokers worldwide at high risk for this fatal malignancy. We are currently lagging in our knowledge of the early molecular (e.g., genomic) effects of smoking in NSCLC pathogenesis that would constitute ideal markers for early detection. This limitation is further amplified when considering the variable etiologic factors in NSCLC pathogenesis among different regions around the globe. In this review, we present our current knowledge of genomic alterations arising during early stages of smoking-induced lung cancer initiation and progression, including discussing the premalignant airway field of injury induced by smoking. The review also underscores the wider spectra and higher age-adjusted rates of tobacco (e.g., water-pipe smoke) consumption, along with elevated environmental carcinogenic exposures and relatively poorer socioeconomic status, in low-middle income countries (LMICs), with Lebanon as an exemplar. This “cocktail” of carcinogenic exposures warrants the pressing need to understand the complex etiology of lung malignancies developing in LMICs such as Lebanon.
登录
查看更多内容
影响因子：
10.4
作者：
Armstrong B;Hutchinson E;Unwin J;Fletcher T
通讯作者：
Fletcher T
影响因子：
5
作者：
Brüske-Hohlfeld, I;Möhner, M;Jöckel, KH
通讯作者：
Jöckel, KH
影响因子：
51.1
作者：
Bray, Freddie;Jemal, Ahmedin;Forman, David
通讯作者：
Forman, David
影响因子：
5.2
作者：
El-Zaatari ZM;Chami HA;Zaatari GS
通讯作者：
Zaatari GS
抗肿瘤相关抗原的自身抗体在肺癌早期检测中的应用
影响因子：
5.3
作者：
Dai, Liping;Tsay, Jun-Chieh J.;Zhang, Jian-Ying
通讯作者：
Zhang, Jian-Ying