Degradability and biocompatibility of bioglass/poly(amino acid) composites with different surface bioactivity as bone repair materials
Degradability and biocompatibility of bioglass/poly(amino acid) composites with different surface bioactivity as bone repair materials
复制标题
不同表面生物活性的生物玻璃/聚氨基酸复合材料作为骨修复材料的降解性和生物相容性
DOI：
10.1002/app.49751
复制
发表时间：
2021-02
影响因子：
3
通讯作者：
Lv Guoyu
中科院分区：
文献类型：
--
作者：
Zheng Heng;Dai Zhenyu;Wei Jie;Li Lin;Peng Haitao;Yang Aiping;Li Hong;Lv Guoyu
生物玻璃具有良好的生物活性，在生物材料的制备中得到了广泛的应用。本研究通过原位熔融聚合的方法，将BG和聚氨基酸（PAA）以合适的比例复合，制备了具有不同表面生物活性的复合材料。用傅里叶变换红外光谱和X射线衍射对复合材料的结构进行了表征。BG/PAA复合材料的压缩强度为139 MPa（BG：PAA = 30：70）。BG/PAA复合材料在模拟体液中孵育4周后可降解，且BG越高，复合材料的失重率越高。此外，BG/PAA复合材料在降解期间保持了足够的剩余压缩强度。扫描电镜结果直接显示了复合材料表面生物活性的差异，30 BG/PAA复合材料比15 BG/PAA复合材料具有更厚的磷灰石层和更高的Ca/p。体外MG-63细胞培养实验表明，该复合材料无细胞毒性，因此允许细胞粘附、增殖和分化。这表明该复合材料具有良好的生物相容性。观察4周和12周兔骨缺损的修复情况。该复合材料具有良好的生物相容性，能够引导新骨形成而不会引起任何炎症。该复合材料可成功地用于骨植入物的开发。
Bioglass (BG) possesses excellent bioactivity and has been widely used in the manufacture of biomaterials. In this study, a composite with different surface bioactivity was fabricated via in situ melting polymerization by incorporating BG and poly(amino acid) (PAA) at a suitable ratio. The structure of the composite was characterized by Fourier transform infrared spectroscopy and XRD. The compressive strength of the BG/PAA composites was 139 MPa (BG:PAA = 30:70). The BG/PAA composites were degradable, and higher BG in composite showed higher weight loss after 4 weeks of incubation in simulated body fluid. In addition, the BG/PAA composite maintained adequate residual compressive strength during the degradation period. The SEM results showed the differences in surface bioactivities of the composites directly, and 30BG/PAA composite showed thicker apatite layer and higher Ca/p than 15BG/PAA. in vitro MG‐63 cell culture experiments showed that the composite was noncytotoxic and thus allows cells to adhere, proliferate, and differentiate. This indicates that the composite has good biocompatibility. The implantations in the bone defects of rabbits for 4 and 12 weeks were studied. The composites had good biocompatibility and were capable of guiding new bone formation without causing any inflammation. The composite may be successfully used in the development of bone implants.
登录
查看更多内容
DOI：
10.1016/j.jmbbm.2018.01.005
发表时间：
2018-03-01
影响因子：
3.9
作者：
Singh, Amardeep;Singh, Gurbhinder;Chawla, Vikas
通讯作者：
Chawla, Vikas
影响因子：
9.7
作者：
Rahaman, Mohamed N.;Day, Delbert E.;Bal, B. Sonny;Fu, Qiang;Jung, Steven B.;Bonewald, Lynda F.;Tomsia, Antoni P.
通讯作者：
Tomsia, Antoni P.
纳米级生物活性玻璃的形态控制及体外生物活性
影响因子：
3.5
作者：
Chen, Xiaofeng;Lei, Bo;Zhao, Naru
通讯作者：
Zhao, Naru
影响因子：
6.7
作者：
Zamet, JS;Darbar, UR;Newman, HN
通讯作者：
Newman, HN
影响因子：
1.8
作者：
Jones, JR;Hench, LL
通讯作者：
Hench, LL