Bioactive glass in tissue engineering.
Bioactive glass in tissue engineering.
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DOI：
10.1016/j.actbio.2011.03.016
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发表时间：
2011-06
影响因子：
9.7
通讯作者：
Tomsia, Antoni P.
中科院分区：
文献类型：
--
作者：
Rahaman, Mohamed N.;Day, Delbert E.;Bal, B. Sonny;Fu, Qiang;Jung, Steven B.;Bonewald, Lynda F.;Tomsia, Antoni P.
本文综述了近年来生物活性玻璃在组织工程中的应用进展。尽管生物活性玻璃具有固有的脆性，但它作为骨组织工程支架材料具有许多吸引人的特性。与硅酸盐生物活性玻璃相比，基于硼酸盐和硼硅酸盐组合物的新型生物活性玻璃显示出增强新骨形成的能力。基于硼酸盐的生物活性玻璃还具有可控的降解速率，因此生物活性玻璃植入物的降解可以与新骨形成的速率更紧密地匹配。生物活性玻璃可以掺杂微量元素，如Cu，Zn和Sr，这些元素已知对健康的骨骼生长有益。除了新的生物活性玻璃之外，生物材料加工的最新进展已经导致创建具有一系列机械性能的支架结构，这些机械性能适用于替代负载和非负载骨。虽然生物活性玻璃已被广泛研究用于骨修复，但生物活性玻璃在软组织修复中的应用研究相对较少。然而，最近的研究表明，生物活性玻璃具有促进血管生成的能力，这对组织再生中的许多应用至关重要，例如用于骨再生的新血管形成和软组织伤口的愈合。生物活性玻璃还显示在软骨细胞接种的水凝胶的体外培养期间增强新软骨形成，并用作组织工程化骨软骨构建物的软骨下基质。分析了在这些组织工程应用中用于操纵生物活性玻璃的结构和性能的方法。
This review focuses on recent advances in the development and use of bioactive glass for tissue engineering applications. Despite its inherent brittleness, bioactive glass has several appealing characteristics as a scaffold material for bone tissue engineering. New bioactive glasses based on borate and borosilicate compositions have shown the ability to enhance new bone formation when compared to silicate bioactive glass. Borate-based bioactive glasses also have controllable degradation rates, so the degradation of the bioactive glass implant can be more closely matched to the rate of new bone formation. Bioactive glasses can be doped with trace quantities of elements such as Cu, Zn and Sr, which are known to be beneficial for healthy bone growth. In addition to the new bioactive glasses, recent advances in biomaterials processing have resulted in the creation of scaffold architectures with a range of mechanical properties suitable for the substitution of loaded as well as non-loaded bone. While bioactive glass has been extensively investigated for bone repair, there has been relatively little research on the application of bioactive glass to the repair of soft tissues. However, recent work has shown the ability of bioactive glass to promote angiogenesis, which is critical to numerous applications in tissue regeneration, such as neovascularization for bone regeneration and the healing of soft tissue wounds. Bioactive glass has also been shown to enhance neocartilage formation during in vitro culture of chondrocyte-seeded hydrogels, and to serve as a subchondral substrate for tissue-engineered osteochondral constructs. Methods used to manipulate the structure and performance of bioactive glass in these tissue engineering applications are analyzed.
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影响因子：
14
作者：
Apelt, D;Theiss, F;von Rechenberg, B
通讯作者：
von Rechenberg, B
影响因子：
14
作者：
Chen, QZZ;Thompson, ID;Boccaccini, AR
通讯作者：
Boccaccini, AR
影响因子：
14
作者：
Bohner, Marc;Lemaitre, Jacques
通讯作者：
Lemaitre, Jacques
影响因子：
14
作者：
Ahmed, I;Lewis, M;Knowles, JC
通讯作者：
Knowles, JC
DOI：
10.1002/jbm.b.31571
发表时间：
2010-04-01
影响因子：
3.4
作者：
Bal, B. Sonny;Rahaman, Mohamed N.;Cook, James L.
通讯作者：
Cook, James L.