Adaptation of the Arizona Cognitive Task Battery for use with the Ts65Dn mouse model (Mus musculus) of Down syndrome.
Adaptation of the Arizona Cognitive Task Battery for use with the Ts65Dn mouse model (Mus musculus) of Down syndrome.
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DOI：
10.1037/com0000069
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Kesner RP
中科院分区：
文献类型：
--
作者：
Hunsaker MR;Smith GK;Kesner RP
我们提出并验证了一种清晰的策略来有效和全面地表征唐氏综合症Ts65Dn小鼠模型的神经行为缺陷。这一新方法使用神经认知理论来设计和选择行为任务，以测试有关唐氏综合症结果的特定假设。在这份手稿中，我们在Ts65Dn小鼠身上建立了亚利桑那州认知任务组的模型，用于研究患有唐氏综合症的人群。我们观察到空间记忆的特殊缺陷，视觉物体的长期记忆受损，运动反应的获得和逆转，运动灵活性降低，以及通过嵌套和焦虑任务测量的适应功能受损。Ts65Dn小鼠表现出完整的时间顺序、新颖性检测和短延迟的视觉对象识别。这些结果与唐氏综合症参与者在亚利桑那州认知任务组合上的表现相似。这种方法通过将临床神经学和认知神经科学的专业知识整合到小鼠行为实验室中，扩展了唐氏综合症小鼠模型的实用性。此外，通过直接强调人类疾病状态和相关小鼠模型之间研究的相互转换，我们证明了这两组人有可能相互告知对方的研究，以更有效地产生假设和阐明治疗策略。
We propose and validate a clear strategy to efficiently and comprehensively characterize neurobehavioral deficits in the Ts65Dn mouse model of Down syndrome. This novel approach uses neurocognitive theory to design and select behavioral tasks that test specific hypotheses concerning the results of Down syndrome. In this manuscript we model in Ts65Dn mice the Arizona Cognitive Task Battery used to study human populations with Down syndrome. We observed specific deficits for spatial memory, impaired long-term memory for visual objects, acquisition and reversal of motor responses, reduced motor dexterity, and impaired adaptive function as measured by nesting and anxiety tasks. The Ts65Dn mice showed intact temporal ordering, novelty detection, and visual object recognition with short delays. These results phenocopy the performance of participants with Down syndrome on the Arizona Cognitive Task Battery. This approach extends the utility of mouse models of Down syndrome by integrating the expertise of clinical neurology and cognitive neuroscience into the mouse behavioral laboratory. Further, by directly emphasizing the reciprocal translation of research between human disease states and the associated mouse models, we demonstrate that it is possible for both groups to mutually inform each others’ research to more efficiently generate hypotheses and elucidate treatment strategies.
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影响因子：
3.2
作者：
CONNOLLY, BH;MICHAEL, BT
通讯作者：
MICHAEL, BT
影响因子：
2.7
作者：
Cummings, Brian J.;Engesser-Cesar, Christie;Anderson, Aileen J.
通讯作者：
Anderson, Aileen J.
影响因子：
1.9
作者：
Goodrich-Hunsaker, Naomi J.;Hunsaker, Michael R.;Kesner, Raymond P.
通讯作者：
Kesner, Raymond P.
DOI：
10.1073/pnas.0404965101
发表时间：
2004-09-07
影响因子：
11.1
作者：
Gallistel, CR;Fairhurst, S;Balsam, P
通讯作者：
Balsam, P
影响因子：
2.9
作者：
Baumann O;Mattingley JB
通讯作者：
Mattingley JB