Vaping and Lung Inflammation and Injury.
Vaping and Lung Inflammation and Injury.
复制标题
蒸发和肺部炎症和损伤。
DOI:
10.1146/annurev-physiol-061121-040014
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发表时间:
2022-02-10
影响因子:
18.2
通讯作者:
中科院分区:
文献类型:
--
作者:
The use of electronic (e)-cigarettes was initially considered a beneficial solution to conventional cigarette smoking cessation. However, paradoxically, e-cigarette use is rapidly growing among nonsmokers, including youth and young adults. In 2019, this rapid growth resulted in an epidemic of hospitalizations and deaths of e-cigarette users (vapers) due to acute lung injury; this novel disease was termed e-cigarette or vaping use-associated lung injury (EVALI). Pathophysiologic mechanisms of EVALI likely involve cytotoxicity and neutrophilic inflammation caused by inhaled chemicals, but further details remain unknown. The undiscovered mechanisms of EVALI are a barrier to identifying biomarkers and developing therapeutics. Furthermore, adverse effects of e-cigarette use have been linked to chronic lung diseases and systemic effects on multiple organs. In this comprehensive review, we discuss the diverse spectrum of vaping exposures, epidemiological and clinical reports, and experimental findings to provide a better understanding of EVALI and the adverse health effects of chronic e-cigarette exposure.
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影响因子:
4.6
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Paolini M
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Cassee FR
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通讯作者:
Kulkarni, Ritwij
DOI:
10.1152/ajplung.00304.2018
发表时间:
2019-03-01
影响因子:
4.9
作者:
Clapp, Phillip W.;Lavrich, Katelyn S.;Jaspers, Ilona
通讯作者:
Jaspers, Ilona
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10.4
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通讯作者:
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