Vaping and Lung Inflammation and Injury.

Vaping and Lung Inflammation and Injury.
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蒸发和肺部炎症和损伤。

DOI:
10.1146/annurev-physiol-061121-040014
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发表时间:
2022-02-10
影响因子:
18.2
通讯作者:
--
中科院分区:
医学1区
文献类型:
--
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电子香烟的使用最初被认为是传统戒烟的一种有益的解决方案。然而,矛盾的是,电子烟的使用在不吸烟者中迅速增长,包括年轻人和年轻人。2019年,这种快速增长导致电子烟使用者因急性肺损伤住院和死亡的流行;这种新型疾病被称为电子烟或电子烟使用相关肺损伤(EVALI)。EVALI的病理生理机制可能涉及吸入化学物质引起的细胞毒性和中性粒细胞炎症,但进一步的细节尚不清楚。EVALI未被发现的机制是识别生物标志物和开发治疗方法的障碍。此外,使用电子烟的不良影响与慢性肺病和对多个器官的全身性影响有关。在这篇综合综述中,我们讨论了电子烟暴露的不同范围、流行病学和临床报告以及实验结果,以更好地了解EVALI和慢性电子烟暴露对健康的不良影响。
The use of electronic (e)-cigarettes was initially considered a beneficial solution to conventional cigarette smoking cessation. However, paradoxically, e-cigarette use is rapidly growing among nonsmokers, including youth and young adults. In 2019, this rapid growth resulted in an epidemic of hospitalizations and deaths of e-cigarette users (vapers) due to acute lung injury; this novel disease was termed e-cigarette or vaping use-associated lung injury (EVALI). Pathophysiologic mechanisms of EVALI likely involve cytotoxicity and neutrophilic inflammation caused by inhaled chemicals, but further details remain unknown. The undiscovered mechanisms of EVALI are a barrier to identifying biomarkers and developing therapeutics. Furthermore, adverse effects of e-cigarette use have been linked to chronic lung diseases and systemic effects on multiple organs. In this comprehensive review, we discuss the diverse spectrum of vaping exposures, epidemiological and clinical reports, and experimental findings to provide a better understanding of EVALI and the adverse health effects of chronic e-cigarette exposure.
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