Endometriosis and organochlorinated environmental pollutants: a case-control study on Italian women of reproductive age.
Endometriosis and organochlorinated environmental pollutants: a case-control study on Italian women of reproductive age.
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DOI：
10.1289/ehp.0800273
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发表时间：
2009-07
影响因子：
10.4
通讯作者：
De Felip E
中科院分区：
文献类型：
--
作者：
Porpora MG;Medda E;Abballe A;Bolli S;De Angelis I;di Domenico A;Ferro A;Ingelido AM;Maggi A;Panici PB;De Felip E
子宫内膜异位症是一种常见的妇科疾病，其特征是子宫内膜组织异位生长。在工业化国家，它影响了大约 10% 的育龄妇女。其病因尚不清楚，但多因素起源被认为是最合理的。据推测，环境有机氯化持久性污染物，特别是二恶英和多氯联苯 (PCB) 在该疾病的发病机制中发挥着一定作用。然而，对人类进行的研究结果是相互矛盾的。我们评估了有机氯化持久性污染物的暴露作为子宫内膜异位症的危险因素。我们在罗马对 158 名女性进行了一项病例对照研究，其中包括 80 名病例和 78 名对照。通过离子阱质谱法测定所有女性中选定的非二恶英类 PCB (NDL-PCB) 和二恶英类 PCB (DL-PCB)、1,1-二氯-2,2,-双(4-氯苯基)-乙烯 (p,p'-DDE) 和六氯苯 (HCB) 的血清浓度。采用 DR-CALUX 生物测定法评估多氯二苯并-对二恶英 (PCDD)、多氯二苯并呋喃 (PCDF) 和 DL-PCB 的 2,3,7,8-四氯二苯并-对二恶英毒性当量 (TEQ) 浓度。我们发现 DL-PCB-118 患子宫内膜异位症的风险增加[比值比 (OR) = 3.79； 95% 置信区间 (CI)，1.61–8.91]、NDL-PCB-138（OR = 3.78；95% CI，1.60–8.94）、NDL-PCB-153（OR = 4.88；95% CI，2.01–11.0）、NDL-PCB-170（OR = 3.52；95% CI， 1.41–8.79），以及 DL-PCB 和 NDL-PCB 之和（OR = 5.63；95% CI，2.25–14.10）。对于 HCB 或作为总 TEQ 给出的 PCDD、PCDF 和 DL-PCB 的总和，没有观察到显着关联。这项研究的结果表明，PCB 和 p,p'-DDE 血清浓度升高与子宫内膜异位症风险之间存在关联。
Endometriosis is a common gynecologic disease characterized by the ectopic growth of endometrial tissue. In industrialized countries, it affects approximately 10% of women of reproductive age. Its etiology is unclear, but a multifactorial origin is considered to be most plausible. Environmental organochlorinated persistent pollutants, in particular dioxins and polychlorinated biphenyls (PCBs), have been hypothesized to play a role in the disease etiopathogenesis. However, results of studies carried out on humans are conflicting. We evaluated the exposure to organochlorinated persistent pollutants as a risk factor for endometriosis. We conducted a case–control study in Rome on 158 women comprising 80 cases and 78 controls. In all women, serum concentrations of selected non-dioxin-like PCBs (NDL-PCBs) and dioxin-like PCBs (DL-PCBs), 1,1-dichloro-2,2,-bis(4-chlorophenyl)-ethene (p,p′-DDE), and hexachlorobenzene (HCB) were determined by ion-trap mass spectrometry. DR-CALUX bioassay was employed to assess the 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity equivalent (TEQ) concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and DL-PCBs. We found an increased risk of endometriosis for DL-PCB-118 [odds ratio (OR) = 3.79; 95% confidence interval (CI), 1.61–8.91], NDL-PCB-138 (OR = 3.78; 95% CI, 1.60–8.94), NDL-PCB-153 (OR = 4.88; 95% CI, 2.01–11.0), NDL-PCB-170 (OR = 3.52; 95% CI, 1.41–8.79), and the sum of DL-PCBs and NDL-PCBs (OR = 5.63; 95% CI, 2.25–14.10). No significant associations were observed with respect to HCB or to the sum of PCDDs, PCDFs, and DL-PCBs given as total TEQs. The results of this study show that an association exists between increased PCB and p,p′-DDE serum concentrations and the risk of endometriosis.
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影响因子：
2.6
作者：
Fierens, S;Mairesse, H;Bernard, A
通讯作者：
Bernard, A
影响因子：
5.6
作者：
Hoffman, Caroline S.;Small, Chanley M.;Marcus, Michele
通讯作者：
Marcus, Michele
DOI：
10.1016/s0889-8545(05)70302-8
发表时间：
1997-06-01
影响因子：
3.2
作者：
Eskenazi, B;Warner, ML
通讯作者：
Warner, ML
影响因子：
6.7
作者：
Donnez, J;Nisolle, M;CasanasRoux, F
通讯作者：
CasanasRoux, F
影响因子：
6.1
作者：
Ertunc, D;Aban, M;Dilek, S
通讯作者：
Dilek, S