The effects of on-site measured ozone concentration on pulmonary function and symptoms of asthmatics.
The effects of on-site measured ozone concentration on pulmonary function and symptoms of asthmatics.
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DOI：
10.3346/jkms.2007.22.1.30
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发表时间：
2007-02
影响因子：
4.5
通讯作者：
Jee YK
中科院分区：
文献类型：
--
作者：
Kim DH;Kim YS;Park JS;Kwon HJ;Lee KY;Lee SR;Jee YK
大多数关于环境臭氧对哮喘患者影响的研究都是基于市中心空气监测仪测量的臭氧浓度。使用被动式臭氧采样器，研究了现场臭氧浓度对哮喘患者肺功能和症状的影响。纳入2005年6月3日至7月18日入选的中、重度哮喘患者20例，治疗至少2个月，未更换药物。在研究期间，每天记录呼吸、鼻部和眼部症状、每天两次测量的最大呼气流量(PEF)和用药情况。对17名受试者的数据进行了分析。臭氧平均暴露水平为28.2ppb±23.6ppb(3.4-315.3 ppb)。在同一天或1天、2天或3天的滞后时间，PEF与臭氧浓度(p>；0.05)没有显著的相关性。有趣的是，哮喘症状的程度受到臭氧浓度的影响(ρ=0.303，p<；0.001)，即使浓度低于80 ppb(p=0.298，p<；0.001)，但臭氧暴露与缓解药物使用频率之间的相关性并不具有统计学意义(p=0.99)。我们的结果表明，暴露在相对低浓度的臭氧中会影响中到重度哮喘患者的症状，无论肺功能或药物使用的变化如何。
Most studies on the effects of ambient ozone on asthmatics have been based on ozone concentration measurements taken by air monitors in downtown areas. Using a passive ozone sampler, we investigated the effects of on-site ozone concentrations on the pulmonary function and symptoms of asthmatics. Twenty moderate to severe asthmatics who had been managed for at least 2 months without changes of their medication were enrolled from 3 June to 18 July 2005. Respiratory, nasal and ocular symptoms, peak expiratory flow (PEF), which was measured twice a day, and medication use were recorded on a daily basis during the study period. Data for 17 subjects were analyzed. The average ozone exposure level was 28.2±23.6 ppb (3.4-315.3 ppb). There was no significant correlation between PEF and ozone concentration (p>0.05) on the same day or 1-, 2-, or 3-day lags. Interestingly, the degree of asthma symptoms was influenced by the ozone concentration (ρ=0.303, p<0.001), even at concentrations less than 80 ppb (p=0.298, p<0.001), but the correlation between ozone exposure and the frequency of reliever medication use was not statistically significant (p=0.99). Our results suggest that exposure to relatively low concentrations of ozone influences the symptoms of moderate to severe asthmatics regardless of changes in pulmonary function or medication use.
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影响因子：
6.1
作者：
Holz, O;Mücke, M;Jörres, RA
通讯作者：
Jörres, RA
影响因子：
5.9
作者：
Peden, DB
通讯作者：
Peden, DB
DOI：
10.1164/rccm.2201013
发表时间：
2002-10-15
影响因子：
24.7
作者：
Vagaggini, B;Taccola, M;Paggiaro, PL
通讯作者：
Paggiaro, PL
DOI：
10.1080/15287399409531838
发表时间：
1994-02-01
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH
影响因子：
--
作者：
JAKAB, GJ;HEMENWAY, DR
通讯作者：
HEMENWAY, DR
影响因子：
6.1
作者：
Bosson, J;Stenfors, N;Blomberg, A
通讯作者：
Blomberg, A