Functional imaging of an alcohol-Implicit Association Test (IAT).
Functional imaging of an alcohol-Implicit Association Test (IAT).
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DOI：
10.1111/adb.12071
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发表时间：
2014-05
影响因子：
3.4
通讯作者：
Bechara A
中科院分区：
文献类型：
--
作者：
Ames SL;Grenard JL;He Q;Stacy AW;Wong SW;Xiao L;Xue G;Bechara A
本研究通过对酒精-内隐联想测试（IAT）的成像（功能磁共振成像）评估了参与内隐联想过程的神经基质的激活情况，该测试主要关注酒精使用的积极结果。在相容和不相容的联想任务试验中，17名重度饮酒者和19名轻度饮酒者参与了比较，年龄从18岁到22岁不等。在行为上，重度饮酒者比轻度饮酒者对酒精使用表现出更强的积极内隐联系，这一显著的IAT效应被发现。成像数据显示，在相容试验中，重度饮酒者的左壳核和脑岛的活动比不相容试验更活跃，而在轻度饮酒者中，两种情况下的活动没有显著差异。在相容试验和不相容试验中，轻度饮酒者的左眶额叶皮层明显比重度饮酒者活跃，而在不相容试验中，轻度饮酒者和重度饮酒者的背外侧前额叶皮层都比相容试验中活跃。此外，组内分析显示，在兼容试验中，与不兼容试验相比，重度饮酒者的杏仁核、壳核和脑岛活动显著。这些结果与食欲行为的双重过程框架一致，即：(1)习惯下的内隐联想是通过依赖纹状体的神经回路介导的，(2)控制行为是通过更依赖前额叶皮层的神经回路介导的。这是第一个评估酒精诱发的神经机制的研究，为增加对联想习惯过程及其对成瘾行为的调节影响的理解提供了额外的一步。
This research assessed activation in neural substrates involved in implicit associative processes through the imaging (functional magnetic resonance imaging) of an alcohol-Implicit Association Test (IAT) focused on positive outcomes of alcohol use. Comparisons involved 17 heavy and 19 light drinkers, ranging in age from 18 to 22, during compatible and incompatible association task trials. Behaviorally, a significant IAT effect was found with heavy drinkers showing stronger positive implicit associations toward alcohol use than light drinkers. Imaging data revealed heavy drinkers showed greater activity during compatible trials relative to incompatible trials in the left putamen and insula while no significant difference in activity between conditions was found in the light drinkers. Light drinkers showed significantly more activity in the left orbital frontal cortex during both compatible and incompatible trials than heavy drinkers, and the dorsolateral prefrontal cortex was engaged more in both light and heavy drinkers during incompatible trials relative to compatible trials. Further, within-group analyses showed significant amygdala activity along with the putamen and insula among heavy drinkers during compatible trials relative to incompatible trials. These results are consistent with a dual process framework of appetitive behaviors proposing that (1) implicit associations underlying habit are mediated through neural circuitry dependent on the striatum, and (2) controlled behaviors are mediated through neural circuitry more dependent on the prefrontal cortex. This is the first study to evaluate the neural mechanisms elicited by an alcohol-IAT, providing an additional step toward increasing understanding of associative habit processes and their regulatory influence over addictive behaviors.
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影响因子：
3.6
作者：
Crews, Fulton Timm;Boettiger, Charlotte Ann
通讯作者：
Boettiger, Charlotte Ann
影响因子：
64.8
作者：
Barnes, TD;Kubota, Y;Graybiel, AM
通讯作者：
Graybiel, AM
影响因子：
10.6
作者：
Corbit, Laura H.;Nie, Hong;Janak, Patricia H.
通讯作者：
Janak, Patricia H.
DOI：
10.1016/j.jbtep.2004.05.001
发表时间：
2004-12-01
影响因子：
1.8
作者：
De Houwer, J;Crombez, G;De Beul, N
通讯作者：
De Beul, N
DOI：
10.1111/j.1530-0277.1995.tb01554.x
发表时间：
1995-06-01
影响因子：
3.2
作者：
BOHN, MJ;KRAHN, DD;STAEHLER, BA
通讯作者：
STAEHLER, BA