Image-guided selection of Gd@C-dots as sensitizers to improve radiotherapy of non-small cell lung cancer.
Image-guided selection of Gd@C-dots as sensitizers to improve radiotherapy of non-small cell lung cancer.
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DOI：
10.1186/s12951-021-01018-9
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发表时间：
2021-09-22
影响因子：
10.2
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Ma X;Lee C;Zhang T;Cai J;Wang H;Jiang F;Wu Z;Xie J;Jiang G;Li Z
最近，钆插入碳点（Gd@C-dots）已显示出潜在的优势，传统的高Z纳米粒子（HZNP）作为放射增敏剂，由于其高稳定性，最小的金属泄漏，和显着的疗效。在这项工作中，制备了两种Gd@ C-dot制剂，其分别在碳壳上带有羧酸（CA-Gd@ C-dot）或氨基（pPD-Gd@ C-dot）。虽然开发用于癌症治疗的创新纳米材料至关重要，但确定其肿瘤积累和保留同样重要。因此，进行体内正电子发射断层扫描（PET），其发现与CA-Gd@ C-dot相比，64 Cu标记的pPD-Gd@ C-dot表现出显著改善的肿瘤保留（注射后长达48小时）。实际上，与64 Cu-CA-Gd@ C-点的约5%相比，64 Cu-pPD-Gd@ C-点的细胞摄取达到接近总剂量的60%。因此，进一步评估pPD-Gd@C-dots作为用于非小细胞肺癌治疗的新放射增敏剂。虽然单剂量辐射加瘤内注射pPD-Gd@C-dots确实导致改善的肿瘤抑制，但是用两个剂量的辐射进一步改善了抑制效果。pPD-Gd@ C-dot在肿瘤区域中的持久保留消除了再次注射放射增敏剂用于第二次放射的需要。PET提供了一种简单而直接的方法来研究纳米粒子在体内的滞留，所选择的pPD-Gd@C-dots具有作为有效的放射增敏剂的巨大潜力。在线版本包含补充材料，可通过10.1186/s12951-021-01018-9获得。
Recently, gadolinium-intercalated carbon dots (Gd@C-dots) have demonstrated potential advantages over traditional high-Z nanoparticles (HZNPs) as radiosensitizers due to their high stability, minimal metal leakage, and remarkable efficacy. In this work, two Gd@C-dots formulations were fabricated which bore carboxylic acid (CA-Gd@C-dots) or amino group (pPD-Gd@C-dots), respectively, on the carbon shell. While it is critical to develop innovative nanomateirals for cancer therapy, determining their tumor accumulation and retention is equally important. Therefore, in vivo positron emission tomography (PET) was performed, which found that 64Cu-labeled pPD-Gd@C-dots demonstrated significantly improved tumor retention (up to 48 h post injection) compared with CA-Gd@C-dots. Indeed, cell uptake of 64Cu-pPD-Gd@C-dots reached close to 60% of total dose compared with ~ 5% of 64Cu-CA-Gd@C-dots. pPD-Gd@C-dots was therefore further evaluated as a new radiosensitizer for non-small cell lung cancer treatment. While single dose radiation plus intratumorally injected pPD-Gd@C-dots did lead to improved tumor suppression, the inhibition effect was further improved with two doses of radiation. The persistent retention of pPD-Gd@C-dots in tumor region eliminates the need of reinjecting radiosensitizer for the second radiation. PET offers a simple and straightforward way to study nanoparticle retention in vivo, and the selected pPD-Gd@C-dots hold great potential as an effective radiosensitizer. The online version contains supplementary material available at 10.1186/s12951-021-01018-9.
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影响因子：
3.6
作者：
Baskar R;Lee KA;Yeo R;Yeoh KW
通讯作者：
Yeoh KW
影响因子：
14
作者：
Deng, Junjie;Xu, Shandong;Su, Ming
通讯作者：
Su, Ming
影响因子：
4.7
作者：
Ma, Xiaofen;Wang, Mengzhe;Li, Zibo
通讯作者：
Li, Zibo
DOI：
10.1007/978-3-319-40389-2_5
发表时间：
2016-01-01
期刊：
LUNG CANCER: TREATMENT AND RESEARCH
影响因子：
--
作者：
Sampath, Sagus
通讯作者：
Sampath, Sagus
钆——用于成像的封装石墨烯碳纳米治疗学——引导光动力治疗
DOI：
10.1002/adma.201802748
发表时间：
2018-07-23
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Chen H;Qiu Y;Ding D;Lin H;Sun W;Wang GD;Huang W;Zhang W;Lee D;Liu G;Xie J;Chen X
通讯作者：
Chen X