Gadolinium-Encapsulated Graphene Carbon Nanotheranostics for Imaging-Guided Photodynamic Therapy.
Gadolinium-Encapsulated Graphene Carbon Nanotheranostics for Imaging-Guided Photodynamic Therapy.
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钆——用于成像的封装石墨烯碳纳米治疗学——引导光动力治疗
DOI：
10.1002/adma.201802748
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发表时间：
2018-07-23
期刊：
影响因子：
--
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Chen H;Qiu Y;Ding D;Lin H;Sun W;Wang GD;Huang W;Zhang W;Lee D;Liu G;Xie J;Chen X
光敏剂(PS)是光动力疗法(PDT)的重要组成部分。传统的PSS通常是卟啉类化合物，与高疏水性、低水溶液中的量子产率以及次优的肿瘤与正常组织(T/N)的选择性有关。已有广泛的努力将光敏剂装载到纳米颗粒载体中以改善药代动力学。然而，这种方法往往受到光敏剂自身猝灭、成熟前释放和网状内皮系统(RES)器官中纳米颗粒积累的限制。在这里，我们报道了一种新型的基于纳米颗粒的光敏剂，它由包裹Gd的石墨烯碳纳米颗粒(Gd@GCNS)制成，具有高1O2量子产率的特点。同时，Gd@GCNS具有很强的荧光和高的T1弛豫度(16.0 mm−1S−1，7T)，使其成为本质上的双模成像探针。Gd@GCNS的尺寸约为5 nm，可通过增强的渗透性和保留力(EPR)效应在肿瘤中蓄积。未结合的Gd@GCNS毒性很小，因为Gd被安全地包裹在惰性碳壳中，而且这些颗粒通过肾脏清除有效地从宿主体内排泄出来。对啮齿动物肿瘤模型的研究表明，Gd@GCNS有可能介导图像引导的光动力疗法用于癌症治疗。总体而言，我们的研究表明，Gd@GCNS具有独特的物理、药物和毒理学性质，是一种具有巨大临床翻译潜力的一体化纳米他汀类工具。透光碳点：合成了包裹Gd的石墨烯碳纳米透光材料，并将其用于成像引导的光动力学治疗。Gd离子在石墨烯结构的形成、独特的吸收和高的单线态氧量子产率中起着重要作用。这些纳米降温工具显示出低毒性，并且在全身注射后可以通过从宿主的肾脏清除有效地排泄。
The photosensitizer (PS) is an essential component of photodynamic therapy (PDT). Conventional PSs are often porphyrin derivatives, which are associated with high hydrophobicity, low quantum yield in aqueous solutions, and suboptimal tumour-to-normal-tissue (T/N) selectivity. There have been extensive efforts to load photosensitizers into nanoparticle carriers to improve pharmacokinetics. The approach, however, is often limited by photosensitizer self-quenching, pre-mature release, and nanoparticle accumulation in the reticuloendothelial system (RES) organs. Herein, we report a novel, nanoparticle-based photosensitizer made of gadolinium-encapsulated graphene carbon nanoparticles (Gd@GCNs), which feature a high 1O2 quantum yield. Meanwhile, Gd@GCNs afford strong fluorescence and high T1 relaxivity (16.0 mM−1s−1, 7 T), making them an intrinsically dual-modal imaging probe. Having a size of approximately 5 nm, Gd@GCNs can accumulate in tumours through the enhanced permeability and retention (EPR) effect. The unbound Gd@GCNs cause little toxicity because Gd is safely encapsulated within an inert carbon shell and because the particles are efficiently excreted from the host through renal clearance. Studies with rodent tumour models demonstrate the potential of the Gd@GCNs to mediate image-guided PDT for cancer treatment. Overall, our studies show that Gd@GCNs possess unique physical, pharmaceutical, and toxicological properties and are an all-in-one nanotheranostic tools with substantial clinical translation potential. Theranostic carbon dots: Gadolinium-encapsulated graphene carbon nanotheranostics are synthesized and utilized for imaging-guided photodynamic therapy. Gd ions play important roles in the formation of graphene structures, unique absorbances and high singlet oxygen quantum yields. These nanotheranostic tools exhibit low-toxicity and can be efficiently excreted by renal clearance from the host after systemic injection.
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DOI：
10.1002/adma.201605928
发表时间：
2017-06
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Chu C;Lin H;Liu H;Wang X;Wang J;Zhang P;Gao H;Huang C;Zeng Y;Tan Y;Liu G;Chen X
通讯作者：
Chen X
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
一种高单线态氧产生量的石墨烯量子点光动力治疗剂
影响因子：
16.6
作者：
Ge, Jiechao;Lan, Minhuan;Zhou, Bingjiang;Liu, Weimin;Guo, Liang;Wang, Hui;Jia, Qingyan;Niu, Guangle;Huang, Xing;Zhou, Hangyue;Meng, Xiangmin;Wang, Pengfei;Lee, Chun-Sing;Zhang, Wenjun;Han, Xiaodong
通讯作者：
Han, Xiaodong
功能化富勒烯在肿瘤治疗学中的应用
影响因子：
12.4
作者：
Chen Z;Ma L;Liu Y;Chen C
通讯作者：
Chen C
影响因子：
5.1
作者：
Kim TH;Lee S;Chen X
通讯作者：
Chen X