Influence of binary microgel phase behavior on the assembly of multi-functional raspberry-structured microgel heteroaggregates.
Influence of binary microgel phase behavior on the assembly of multi-functional raspberry-structured microgel heteroaggregates.
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DOI：
10.1016/j.jcis.2015.05.031
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发表时间：
2015-10-01
影响因子：
9.9
通讯作者：
Lyon, L. Andrew
中科院分区：
文献类型：
--
作者：
Saxena, Shalini;Lyon, L. Andrew
我们研究了微凝胶组成对二元微凝胶分散体相行为的影响，用聚（N-异丙基丙烯酰胺）微凝胶与5 mol-%和1 mol-% N，N ' -亚甲基双（丙烯酰胺）交联，或聚（N-异丙基甲基丙烯酰胺）微凝胶与5 mol-% N，N ' -亚甲基双（丙烯酰胺）交联。然后，我们探讨了微凝胶沉积在平面界面上的色散相行为。然后将这些结果与观察到的微凝胶在弯曲界面上的组装进行比较，以覆盆子状斑块颗粒（RLPPs）的形式，由聚苯乙烯核心组成，由（双组分）微凝胶外壳包围。结果表明，微凝胶组成对二元分散体覆盖平面和曲面界面的能力有很大影响。特别是，我们证明了含有较高交联剂含量的微凝胶的二元分散体在弯曲界面上表现出非常明显的堆积密度降低。为了提高包装密度，我们还探索了使用两步涂层工艺来制造具有增强地形控制的RLPPs。这些复杂载体的发展在分子的时空表现对细胞行为有很大影响的生物系统的调节中具有潜在的益处。
We investigate the influence of microgel composition on phase behavior of binary microgel dispersions using poly(N-isopropylacrylamide) microgels cross-linked with 5 mol-% and 1 mol-% N,N′-methylenebis(acrylamide), or poly(N-isopropylmethacrylamide) microgels cross-linked with 5 mol-% N,N′-methylenebis(acrylamide). We then explore the dispersion phase behavior in the context of microgel deposition at a planar interface. These results are then compared to the observed assembly of microgels at curved interfaces, in the form of raspberry-like patchy particles (RLPPs) consisting of a polystyrene core surrounded by a (two-component) microgel shell. Results suggest that microgel composition has a large influence on the ability of binary dispersions to coat planar and curved interfaces. In particular, we demonstrate that binary dispersions of microgels containing higher cross-linker content exhibit decreased packing densities that are very pronounced at a curved interface. To enhance packing density we also explore the use of a two-step coating process to fabricate RLPPs with enhanced control over topography. Development of these complex vehicles is potentially beneficial in the modulation of biological systems where spatial and temporal presentation of molecules can have a large influence on cellular behavior.
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影响因子：
2.4
作者：
Cheng, Chao-Min;Steward, Robert L., Jr.;LeDuc, Philip R.
通讯作者：
LeDuc, Philip R.
影响因子：
14
作者：
Carpenedo, Richard L.;Bratt-Leal, Andrs M.;Marklein, Ross A.;Seaman, Scott A.;Bowen, Nathan J.;McDonald, John F.;McDevitt, Todd C.
通讯作者：
McDevitt, Todd C.
作为 3D 细胞支架的热凝胶 PNIPAM 微凝胶分散体：脱水收缩效应
影响因子：
--
作者：
Gan, Tiantian;Guan, Ying;Zhang, Yongjun
通讯作者：
Zhang, Yongjun
DOI：
10.1073/pnas.0801866105
发表时间：
2008-07-15
影响因子：
11.1
作者：
Du, Yanan;Lo, Edward;Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
影响因子：
6.1
作者：
Lu J;Li D;Lu K
通讯作者：
Lu K