Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future.
Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future.
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DOI：
10.1039/c2cs15355f
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发表时间：
2012-04-07
影响因子：
46.2
通讯作者：
Mukherjee P
中科院分区：
文献类型：
--
作者：
Arvizo RR;Bhattacharyya S;Kudgus RA;Giri K;Bhattacharya R;Mukherjee P
生物医学纳米技术是一个发展中的领域，具有对医疗保健系统产生积极影响的巨大潜力。纳米技术可能具有潜在临床应用的重要生物医学应用包括靶向药物输送、检测/诊断和成像。对纳米材料--纳米技术的基石--如何与细胞相互作用及其生物学后果的基本了解正在开始演变。贵金属纳米粒子，如金、银和铂，由于其尺寸和形状依赖于独特的光电性质而特别令人感兴趣。这些贵金属纳米粒子，特别是金纳米粒子，由于其易于合成、表征和表面功能化而在重要的生物医学应用中引起了人们的极大兴趣。此外，最近的研究表明，这些纳米材料作为自我治疗的另一种有前途的应用。为了实现这些独特的无机纳米材料在未来临床转化中的潜在希望，了解一些关键参数是至关重要的；(I)这些纳米材料如何在分子水平上与细胞相互作用；(Ii)它们的生物分布和药代动力学如何受到它们的表面和给药途径的影响；(Iii)它们的解毒和清除机制；以及(Iv)它们在适当的疾病模型中的治疗效果。因此，在这篇重要的综述中，我们将讨论与上述参数相关的金、银和铂纳米颗粒的各种临床应用。我们还将提到这些贵金属纳米颗粒的各种合成路线。然而，在我们讨论目前的研究之前，我们也要回顾一下过去。我们需要理解摆在我们面前的发现，以促进我们的知识和技术发展(参考文献318)。
Biomedical nanotechnology is an evolving field having enormous potential to positively impact the health care system. Important biomedical applications of nanotechnology that may have potential clinical applications include targeted drug delivery, detection/diagnosis and imaging. Basic understanding of how nanomaterials, the building blocks of nanotechnology, interact with the cells and their biological consequences are beginning to evolve. Noble metal nanoparticles such as gold, silver and platinum are particularly interesting due to their size and shape dependent unique optoelectronic properties. These noble metal nanoparticles, particularly of gold, have elicited a lot of interest for important biomedical applications because of their ease of synthesis, characterization and surface functionalization. Furthermore, recent investigations are demonstrating another promising application of these nanomaterials as self-therapeutics. To realize the potential promise of these unique inorganic nanomaterials for future clinical translation, it is of utmost importance to understand a few critical parameters; (i) how these nanomaterials interact with the cells at the molecular level; (ii) how their biodistribution and pharmacokinetics influenced by their surface and routes of administration; (iii) mechanism of their detoxification and clearance and (iv) their therapeutic efficacy in appropriate disease model. Thus in this critical review, we will discuss the various clinical applications of gold, silver and platinum nanoparticles with relevance to above parameters. We will also mention various routes of synthesis of these noble metal nanoparticles. However, before we discuss present research, we will also look into the past. We need to understand the discoveries made before us in order to further our knowledge and technological development (318 references).
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影响因子：
15
作者：
Agasti SS;Chompoosor A;You CC;Ghosh P;Kim CK;Rotello VM
通讯作者：
Rotello VM
影响因子：
5
作者：
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通讯作者：
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影响因子：
17.1
作者：
Bartneck, Matthias;Keul, Heidrun A.;Groll, Juergen
通讯作者：
Groll, Juergen
影响因子：
17.1
作者：
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通讯作者：
Chan, Warren C. W.
影响因子：
13.3
作者：
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