Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: Results from the African American Cancer Epidemiology Study.
Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: Results from the African American Cancer Epidemiology Study.
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DOI：
10.1002/cncr.34053
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发表时间：
2022-03-15
期刊：
影响因子：
6.2
通讯作者：
Schildkraut, Joellen M.
中科院分区：
文献类型：
--
作者：
McBride, Colleen M.;Pathak, Sarita;Johnson, Courtney E.;Alberg, Anthony J.;Bandera, Elisa V.;Barnholtz-Sloan, Jill S.;Bondy, Melissa L.;Cote, Michele L.;Moorman, Patricia G.;Peres, Lauren C.;Peters, Edward S.;Schwartz, Ann G.;Terry, Paul D.;Schildkraut, Joellen M.
非裔美国人(AA)女性在接受癌症遗传服务方面的种族差异有很好的记录。需要了解影响再生障碍性贫血妇女接受基因检测的多种社会和心理因素。数据来自270名被诊断患有卵巢癌的AA女性，她们参与了一项以人群为基础的卵巢癌病例对照研究，她们被问及基因测试。Logistic回归分析检验了易感因素、使能因素和需要因素与报告的基因检测摄取率之间的关系。三分之一的样本(35%)报告说曾进行过基因检测。在多变量模型中，收入较高的AA女性接受测试的几率是收入最低的女性的两倍多(优势比[OR]为25,000-74,999美元，2.04；95%可信区间[CI]为1.06-3.99；OR为75,000美元，2.32；95%CI为0.92-5.94)。报告就业歧视的AA妇女报告基因检测的可能性显著低于未报告工作歧视的妇女(OR，0.39；95%CI，0.14-0.95)。婚姻状况、医疗补助与其他保险、祈祷频率和感受到的社会支持在双变量分析中与基因测试吸收显著相关，但在多变量分析中没有显著贡献。与其他对再生障碍性贫血女性的研究一致，少数非裔美国人癌症流行病学研究参与者接受了基因测试。较低的收入和经历的工作歧视降低了测试的可能性。这些结果提供了基本证据，支持需要采取干预措施，通过减少成本障碍和提供可靠的保证，确保遗传结果将保密，不影响就业能力等社会因素，从而提高再生障碍性贫血妇女接受基因检测的能力。收入较低、经历过工作歧视的非裔美国女性不太可能接受测试。这些结果支持需要采取干预措施，以减少成本壁垒，并提供可靠的保证，即遗传结果将保密，不会影响就业能力等社会因素。
Racial disparities in the uptake of cancer genetic services are well documented among African American (AA) women. Understanding the multiple social and psychological factors that can influence the uptake of genetic testing among AA women is needed. Data came from 270 AA women diagnosed with ovarian cancer and participating in a population‐based, case‐control study of ovarian cancer who were asked about genetic testing. Logistic regression analyses tested the associations of predisposing, enabling, and need factors with reported genetic testing uptake. One‐third of the sample (35%) reported having had genetic testing. In the multivariable model, AA women with higher incomes had more than double the odds of being tested than those with the lowest income (odds ratio [OR] for $25,000‐$74,999, 2.04; 95% confidence interval [CI], 1.06‐3.99; OR for ≥$75,000, 2.32; 95% CI, 0.92‐5.94). AA women who reported employment discrimination were significantly less likely to report genetic testing than those who did not report job discrimination (OR, 0.39; 95% CI, 0.14‐0.95). Marital status, Medicaid versus other insurance, prayer frequency, and perceived social support were significantly associated with genetic testing uptake in bivariate analyses but were not significant contributors in multivariable analyses. Consistent with other studies of AA women, a minority of African American Cancer Epidemiology Study participants had undergone genetic testing. Having a lower income and experiencing job discrimination decreased the likelihood of testing. These results provide foundational evidence supporting the need for interventions to improve the uptake of genetic testing among AA women by reducing cost barriers and providing credible assurances that genetic results will be kept private and not affect social factors such as employability. African American women with lower incomes who have experienced job discrimination are less likely to undergo testing. These results support the need for interventions to reduce cost barriers and provide credible assurances that genetic results will be kept private and not affect social factors such as employability.
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影响因子：
5.5
作者：
Mai, Phuong L.;Vadaparampil, Susan Thomas;Breen, Nancy;McNeel, Timothy S.;Wideroff, Louise;Graubard, Barry I.
通讯作者：
Graubard, Barry I.
DOI：
10.1017/s1742058x11000087
发表时间：
2011
期刊：
Du Bois review : social science research on race
影响因子：
--
作者：
Sternthal MJ;Slopen N;Williams DR
通讯作者：
Williams DR
影响因子：
8.8
作者：
Butrick, Morgan;Kelly, Scott;Schwartz, Marc D.
通讯作者：
Schwartz, Marc D.
影响因子：
2.3
作者：
Cuevas, Adolfo G.;Reitzel, Lorraine R.;McNeill, Lorna H.
通讯作者：
McNeill, Lorna H.
影响因子：
3.3
作者：
Sheppard, Vanessa B.;Mays, Darren;Tercyak, Kenneth P.
通讯作者：
Tercyak, Kenneth P.