Awareness of cancer susceptibility genetic testing: the 2000, 2005, and 2010 National Health Interview Surveys.

Awareness of cancer susceptibility genetic testing: the 2000, 2005, and 2010 National Health Interview Surveys.
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DOI:
10.1016/j.amepre.2014.01.002
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发表时间:
2014-05
影响因子:
5.5
通讯作者:
Graubard, Barry I.
Graubard, Barry I.
中科院分区:
医学2区
文献类型:
--
作者:
Mai, Phuong L.;Vadaparampil, Susan Thomas;Breen, Nancy;McNeel, Timothy S.;Wideroff, Louise;Graubard, Barry I.

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几种癌症易感性综合征的基因检测在临床上是可用的;然而,现有的数据表明,有限的人群对此类检测的认识。在2000年、2005年和2010年国家健康访谈调查中,检查美国≥25岁人群对癌症基因检测的认识。计算了了解癌症基因检测的受访者的加权百分比,以及2000-2005年和2005-2010年的百分比变化,总体以及人口统计学,家族史和医疗保健因素。互动被用来评估2005年至2010年期间每个因素内的亚组之间的认识变化模式。为了评估2005年和2010年与意识的关联,使用多元logistic回归对协变量进行了百分比调整。分析是在2012年进行的。2000年至2005年,知晓率从44.4%降至41.5%(p<0.001),2010年增至47.0%(p<0.001)。2005年至2010年,大多数亚组的认识有所提高,特别是南方(p-相互作用=0.03)或有通常护理场所(p-相互作用=0.01)的个人。在2005年和2010年,意识与个人或家族癌症史和高感知癌症风险呈正相关,与种族/少数民族、年龄25-39岁或≥60岁、男性、教育和收入水平较低、公共或无健康保险以及12个月内未联系提供者呈负相关。尽管从2005年到2010年有所改善,但在2010年,≤50%的美国成年人知道癌症基因检测。值得注意的是,种族/族裔少数群体和获得医疗保健或收入有限的个人之间的差距仍然存在。
Genetic testing for several cancer susceptibility syndromes is clinically available; however, existing data suggest limited population awareness of such tests. To examine awareness regarding cancer genetic testing in the U.S. population aged ≥25 years in the 2000, 2005, and 2010 National Health Interview Surveys. The weighted percentages of respondents aware of cancer genetic tests, and percent changes from 2000–2005 and 2005–2010, overall and by demographic, family history, and healthcare factors were calculated. Interactions were used to evaluate the patterns of change in awareness between 2005 and 2010 among subgroups within each factor. To evaluate associations with awareness in 2005 and 2010, percentages were adjusted for covariates using multiple logistic regression. The analysis was performed in 2012. Awareness decreased from 44.4% to 41.5% (p<0.001) between 2000 and 2005, and increased to 47.0% (p<0.001) in 2010. Awareness increased between 2005 and 2010 in most subgroups, particularly among individuals in the South (p-interaction=0.03) or with a usual place of care (p-interaction=0.01). In 2005 and 2010, awareness was positively associated with personal or family cancer history and high perceived cancer risk, and inversely associated with racial/ethnic minorities, age 25–39 or ≥60 years, male gender, lower education and income levels, public or no health insurance, and no provider contact in 12 months. Despite improvement from 2005 to 2010, ≤50% of the U.S. adult population was aware of cancer genetic testing in 2010. Notably, disparities persist for racial/ethnic minorities and individuals with limited health care access or income.
DOI: 10.1016/j.amepre.2010.09.027
发表时间: 2011-01-01
影响因子: 5.5
作者:
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发表时间: 2012-01-01
影响因子: 1.8
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DOI: 10.1089/gte.2007.0024
发表时间: 2008-03-01
期刊: GENETIC TESTING
影响因子: --
作者:
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通讯作者: Einsiedel, Edna