Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds.
Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds.
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DOI：
10.3390/v14061186
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发表时间：
2022-05-29
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影响因子：
--
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中科院分区：
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麻疹病毒（MV）是一种高度传染性的呼吸道病毒，可导致儿童和年轻人的严重发病率和死亡率。尽管有安全有效的麻疹疫苗可供使用，但COVID-19大流行导致疫苗接种覆盖率出现缺口，可能导致限制解除后麻疹死灰复燃。这使那些不能接种疫苗的人，如幼儿和免疫功能低下的人，处于危险之中。治疗干预措施因麻疹潜伏期长而复杂化，导致治疗窗口狭窄。目前，世卫组织建议的唯一可用选择是静脉注射免疫球蛋白治疗，尽管这尚未被批准为标准治疗。抗麻疹病毒药物可能有助于限制未来疫情影响的干预战略。在这里，我们回顾了以前描述的抗病毒药物和抗病毒检测，评估了一些化合物的抗病毒疗效，以抑制MV传播在体外，并讨论在特定的目标人群中的潜在应用。我们的结论是，广泛反应的抗病毒药物可以加强现有的干预策略，以限制麻疹疫情的影响。
Measles virus (MV) is a highly contagious respiratory virus responsible for outbreaks associated with significant morbidity and mortality among children and young adults. Although safe and effective measles vaccines are available, the COVID-19 pandemic has resulted in vaccination coverage gaps that may lead to the resurgence of measles when restrictions are lifted. This puts individuals who cannot be vaccinated, such as young infants and immunocompromised individuals, at risk. Therapeutic interventions are complicated by the long incubation time of measles, resulting in a narrow treatment window. At present, the only available WHO-advised option is treatment with intravenous immunoglobulins, although this is not approved as standard of care. Antivirals against measles may contribute to intervention strategies to limit the impact of future outbreaks. Here, we review previously described antivirals and antiviral assays, evaluate the antiviral efficacy of a number of compounds to inhibit MV dissemination in vitro, and discuss potential application in specific target populations. We conclude that broadly reactive antivirals could strengthen existing intervention strategies to limit the impact of measles outbreaks.
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影响因子：
5.9
作者：
Cox RM;Plemper RK
通讯作者：
Plemper RK
影响因子：
4.2
作者：
Moore, Terry W.;Sana, Kasinath;Yan, Dan;Krumm, Stefanie A.;Thepchatri, Pahk;Snyder, James P.;Marengo, Jose;Arrendale, Richard F.;Prussia, Andrew J.;Natchus, Michael G.;Liotta, Dennis C.;Plemper, Richard K.;Sun, Aiming
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Sun, Aiming
影响因子：
3.7
作者：
Bankamp, B;Horikami, SM;Moyer, SA
通讯作者：
Moyer, SA
影响因子：
5.4
作者：
de Vries, Rory D.;Yuksel, Selma;de Swart, Rik L.
通讯作者：
de Swart, Rik L.
影响因子：
28.3
作者：
Cox RM;Sourimant J;Toots M;Yoon JJ;Ikegame S;Govindarajan M;Watkinson RE;Thibault P;Makhsous N;Lin MJ;Marengo JR;Sticher Z;Kolykhalov AA;Natchus MG;Greninger AL;Lee B;Plemper RK
通讯作者：
Plemper RK