Caffeine Attenuates Electroacupuncture Effect on Pressure Pain Threshold and Tolerance in Healthy Individuals: A Randomized Controlled Trial.
Caffeine Attenuates Electroacupuncture Effect on Pressure Pain Threshold and Tolerance in Healthy Individuals: A Randomized Controlled Trial.
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咖啡因减弱电针对健康个体压痛阈值和耐受性的影响：一项随机对照试验
DOI：
10.3389/fneur.2022.859624
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发表时间：
2022
影响因子：
3.4
通讯作者：
Zhu, Bing
中科院分区：
文献类型：
--
作者：
Liu, Kun;Cui, Xiang;Zhi, Mujun;Zhang, Meng;Zhao, Ting;Gao, Xinyan;Zhu, Bing
关键词：
咖啡因对人类针灸镇痛的影响尚不清楚。本研究旨在探讨含咖啡因饮料的摄入是否影响电针对健康受试者静态定量感觉测试（QST）和动态QST的影响。共招募了40名健康受试者，并随机分配接受含有中等剂量咖啡因的咖啡（咖啡组）或不含咖啡因的果汁（果汁组）4周。主要结局指标为作为静态QST参数的压痛阈值（PPT）、压痛耐受性（PPTo）和热痛阈值（HPT）。热刺激和伤害性屈肌反射（RIII反射）的数字评定量表（NRS），作为动态QST的参数进行了检查。分别于第0、2、4周电针足三里穴-阳陵泉穴，以耐受强度刺激。电针前后检测PPT、PPTo和HPT。分别于电针前、中、后及电针结束后1 min进行NRS评分。在电针前和电针后1-5分钟检查RIII反射。电针后第0周，两组PPT和PPTo均增加，热刺激和RIII反射的NRS评分降低，但HPT不受影响。4周后，咖啡组电针对PPT和PPTo的影响较果汁组减弱，而电针对NRS评分和RIII反射的影响不受影响。在第2周时，这些适应症无显著差异。在第4周，EA也没有影响两组的HPT。适度的咖啡因摄入减少EA对健康受试者PPT和PPTo的影响。
The effect of caffeine on acupuncture analgesia in humans is unclear. This study aimed to investigate whether caffeine-containing beverage intake influences the effect of electroacupuncture (EA) on static quantitative sensory testing (QST) and dynamic QST in healthy subjects. A total of 40 healthy subjects were enrolled and randomly assigned to receive coffee containing moderate doses of caffeine (coffee group) or non-caffeinated juice (juice group) for 4 weeks. The primary outcome measures were the pressure pain threshold (PPT), pressure pain tolerance (PPTo), and heat pain threshold (HPT) as static QST parameters. Numerical rating scales (NRS) of heat stimulus and nociceptive flexor reflex (RIII reflex), as parameters of dynamic QST, were also examined. EA stimulation with tolerance intensity was performed at ST36 (Zusanli)-GB34 (Yanglingquan) points at weeks 0, 2, and 4. PPT, PPTo, and HPT were detected pre- and post- EA. The NRS scores were examined pre-, during, and post-EA, and 1 min after EA was completed. The RIII reflex was examined pre- and 1–5 min post-EA. At week 0, both groups showed increased PPT and PPTo and decreased NRS scores of heat stimuli and RIII reflex after EA, but HPT was not affected. After 4 weeks, the effects of EA on PPT and PPTo were attenuated in the coffee group compared to the juice group, whereas the effect of EA on the NRS scores and RIII reflex were not influenced. There was no significant difference found at week 2 for these indications. EA also did not affect the HPT in both groups at week 4. Moderate caffeine intake reduced the effects of EA on PPT and PPTo in healthy subjects.
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影响因子：
4.6
作者：
Fujita T;Feng C;Takano T
通讯作者：
Takano T
影响因子：
7.4
作者：
Backonja, Miroslav 'Misha'';Attal, Nadine;Ziegler, Dan
通讯作者：
Ziegler, Dan
影响因子：
1
作者：
Itoh, Kazunori;Saito, Shingo;Kitakoji, Hiroshi
通讯作者：
Kitakoji, Hiroshi
影响因子：
120.7
作者：
LASKA, EM;SUNSHINE, A;RUBIN, A
通讯作者：
RUBIN, A
影响因子：
7.4
作者：
Barlas, Panos;Ting, Sharlene L. H.;Sim, Julius
通讯作者：
Sim, Julius