Viral etiology of acute febrile respiratory illnesses in hospitalized children younger than 24 months.
Viral etiology of acute febrile respiratory illnesses in hospitalized children younger than 24 months.
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DOI：
10.1177/0009922810394834
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发表时间：
2011-06
影响因子：
1.6
通讯作者：
Domachowske JB
中科院分区：
文献类型：
--
作者：
Suryadevara M;Cummings E;Bonville CA;Bartholoma N;Riddell S;Kiska D;Rosenberg HF;Domachowske JB
呼吸道感染是儿科住院的主要原因。本研究调查了病毒-病毒或病毒-博德特氏菌混合感染是否比以前认识到的更频繁或更严重。这是一项为期3年的前瞻性研究，研究对象为因发热性呼吸道疾病住院的24个月以下儿童。使用多重聚合酶链反应（PCR），酶联免疫测定和/或鼻咽样本的病毒培养物检测病毒病原体。用PCR检测博德特氏菌感染。共入组201例患者。在187例（93%）患者中检测到呼吸道病毒，其中52例（28%）为多病原体感染。最常见的病毒是呼吸道合胞病毒和鼻病毒/肠道病毒。当比较感染一种病原体和多病原体感染的患者时，疾病严重程度没有差异。病毒合并感染在因急性发热性呼吸道感染住院的幼儿中很常见，但似乎与疾病严重程度无关。
Respiratory infections are a leading cause of pediatric hospitalizations. This study investigated whether virus–virus or virus–Bordetella co-infections are more frequent or more severe than previously recognized. This is a 3-year prospective study of children younger than 24 months hospitalized with a febrile respiratory illness. Viral pathogens were detected using multiplex polymerase chain reaction (PCR), enzyme-linked immunoassays, and/or viral cultures from nasopharyngeal samples. Bordetella infections were detected by PCR. A total of 201 patients were enrolled. Respiratory viruses were detected in 187 (93%) patients, with 52 (28%) multipathogen infections. The most common viruses detected were respiratory syncytial virus and rhinovirus/enterovirus. There were no differences in illness severity when comparing patients infected with one pathogen and those with multipathogen infection. Virus co-infection in young children hospitalized with an acute febrile respiratory infection is common but does not appear to be associated with illness severity.
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DOI：
10.1016/s1386-6532(07)70004-5
发表时间：
2007-11
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Ginocchio CC
通讯作者：
Ginocchio CC
急性呼吸道感染住院儿童的多病原体感染
影响因子：
4.8
作者：
Peng D;Zhao D;Liu J;Wang X;Yang K;Xicheng H;Li Y;Wang F
通讯作者：
Wang F
影响因子：
9.4
作者：
Reijans, Martin;Dingemans, Gijs;Simons, Guus
通讯作者：
Simons, Guus
影响因子：
3.6
作者：
Henrickson, KJ
通讯作者：
Henrickson, KJ
影响因子：
12.7
作者：
Canducci, Filippo;Debiaggi, Maurizia;Clementi, Massimo
通讯作者：
Clementi, Massimo