Family history interview of a broad phenotype in specific language impairment and matched controls
Family history interview of a broad phenotype in specific language impairment and matched controls
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对特定语言障碍的广泛表型和匹配对照的家族史访谈
DOI：
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Hans Forssberg
中科院分区：
文献类型：
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作者：
N. Kalnak;M. Peyrard;Birgitta Sahlén;Hans Forssberg
目的是研究具有特殊语言障碍（SLI）儿童的三代亲属中语言相关诊断和问题的更广泛表型。我们的研究基于对59名特殊语言障碍儿童和100名匹配对照儿童的父母的家族史访谈，探讨了与语言、阅读、注意力、学业成绩和社交沟通相关的问题的患病率，以及诸如注意力缺陷多动障碍（ADHD）、自闭症、阿斯伯格综合症、阅读障碍、智力迟钝、腭裂和口吃等诊断。结果表明，在特殊语言障碍儿童的家庭中存在一系列语言相关问题。在所有三代特殊语言障碍亲属中，我们发现语言、识字和社会沟通问题的患病率明显更高。在患有特殊语言障碍的儿童中，父母一方或双方有语言相关诊断或问题的风险（85%）大约是对照组儿童（13%）的6倍（优势比= 37.2）。我们没有发现患有特殊语言障碍儿童的亲属中诊断为多动症、自闭症或阿斯伯格综合症的患病率明显更高。然而，与对照组的父母相比，患有特殊语言障碍儿童的父母明显有更多的注意力/多动问题。我们的研究结果表明，语言、识字和社会沟通问题的共同潜在机制，也可能是注意力/多动症状的共同潜在机制。
The aim was to study a broader phenotype of language‐related diagnoses and problems in three generations of relatives of children with specific language impairment (SLI). Our study is based on a family history interview of the parents of 59 children with SLI and of 100 matched control children, exploring the prevalence of problems related to language, reading, attention, school achievement and social communication as well as diagnoses such as attention‐deficit hyperactivity disorder (ADHD), autism, Asperger syndrome, dyslexia, mental retardation, cleft palate and stuttering. The results show a spectrum of language‐related problems in families of SLI children. In all three generations of SLI relatives, we found significantly higher prevalence rates of language, literacy and social communication problems. The risk of one or both parents having language‐related diagnoses or problems was approximately six times higher for the children with SLI (85%) than for the control children (13%) (odds ratio = 37.2). We did not find a significantly higher prevalence of the diagnoses ADHD, autism or Asperger syndrome in the relatives of the children with SLI. However, significantly more parents of the children with SLI had problems with attention/hyperactivity when compared with the parents of controls. Our findings suggest common underlying mechanisms for problems with language, literacy and social communication, and possibly also for attention/hyperactivity symptoms.
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双胞胎中语言成绩较差的遗传力。
DOI：
10.1044/jslhr.4101.188
发表时间：
1998
期刊：
Journal of speech, language, and hearing research : JSLHR
影响因子：
--
作者：
Tomblin,JB;Buckwalter,PR
通讯作者：
Buckwalter,PR
有特定语言障碍的儿童的兄弟姐妹患有自闭症和自闭症风险。
DOI：
10.1080/1368282031000086363
发表时间：
2003
影响因子：
2.4
作者：
Tomblin,JBruce;Hafeman,LauraL;O'Brien,Marlea
通讯作者：
O'Brien,Marlea
DOI：
10.1044/jshr.3903.661
发表时间：
1996
期刊：
Journal of speech and hearing research
影响因子：
--
作者：
Plante,E;Shenkman,K;Clark,MM
通讯作者：
Clark,MM
特定语言障碍的家族聚集性。
DOI：
10.1044/1092-4388(2001/091
发表时间：
2001
期刊：
Journal of speech, language, and hearing research : JSLHR
影响因子：
--
作者：
Tallal,P;Hirsch,LS;Realpe-Bonilla,T;Miller,S;Brzustowicz,LM;Bartlett,C;Flax,JF
通讯作者：
Flax,JF
影响因子：
2.6
作者：
Tomblin, JB;Records, NL;O'Brien, M
通讯作者：
O'Brien, M