Life or death: prognostic value of a resting EEG with regards to survival in patients in vegetative and minimally conscious States.
Life or death: prognostic value of a resting EEG with regards to survival in patients in vegetative and minimally conscious States.
复制标题
DOI：
10.1371/journal.pone.0025967
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Galardi G
中科院分区：
文献类型：
--
作者：
Fingelkurts AA;Fingelkurts AA;Bagnato S;Boccagni C;Galardi G
研究静息状态脑电图（EEG）对植物人和最低意识状态（VS和MCS）患者脑损伤后6个月生存率的临床结局的潜在预后价值。我们量化了VS和MCS患者在静息状态下闭眼的EEG振荡的动态库。EEG振荡的确切组成进行了评估，通过分析短期EEG频谱模式的概率分类。结果表明，（a）非幸存者EEG的多样性和变异性显著低于幸存者;（B）在第一次评估期间，发现结局不良的患者（即，那些在受伤后六个月内死亡的人）与幸存的患者相比。同时，具有良好结局的患者（即，在第一次评估中，与在受伤后六个月内死亡的患者相比，在受伤后六个月后存活的患者具有更高的概率，大多数快速θ和α振荡单独或组合发生。正确分析静息状态EEG可能对脑损伤后6个月的生存率方面VS或MCS的结局具有潜在的预后价值。这项工作可能对急性脑损伤昏迷后意识受损患者的临床护理、康复方案和医疗法律决定产生影响。
To investigate the potentially prognostic value of a resting state electroencephalogram (EEG) with regards to the clinical outcome from vegetative and minimally conscious states (VS and MCS) in terms of survival six months after a brain injury. We quantified a dynamic repertoire of EEG oscillations in resting condition with eyes closed in patients in VS and MCS. The exact composition of EEG oscillations was assessed by analysing the probability-classification of short-term EEG spectral patterns. Results demonstrated that (a) the diversity and the variability of EEG for Non-Survivors were significantly lower than for Survivors; and (b) a higher probability of mostly delta and slow-theta oscillations occurring either alone or in combination were found during the first assessment for patients with a bad outcome (i.e., those who died) within six months of an injury compared to patients who survived. At the same time, patients with a good outcome (i.e., those who survived) after six months post-injury had a higher probability of mostly fast-theta and alpha oscillations occurring either alone or in combination during the first assessment when compared to patients who died within six months of an injury. Resting state EEGs properly analysed may have a potentially prognostic value with regards to the outcome from VS or MCS in terms of survival six months after a brain injury. This work may have implications for clinical care, rehabilitative programmes and medical–legal decisions for patients with impaired consciousness states after being in a coma due to acute brain injuries.
登录
查看更多内容
影响因子：
4.7
作者：
Babiloni, Claudio;Sara, Marco;Rossini, Paolo Maria
通讯作者：
Rossini, Paolo Maria
影响因子：
2.9
作者：
Fingelkurts, Alexander A.;Fingelkurts, Andrew A.
通讯作者：
Fingelkurts, Andrew A.
影响因子：
4.7
作者：
Bagnato, S.;Boccagni, C.;Galardi, G.
通讯作者：
Galardi, G.
影响因子：
4.3
作者：
Ferrer, Ricard;Artigas, Antonio
通讯作者：
Artigas, Antonio
影响因子：
1.8
作者：
Freeman, Walter J
通讯作者：
Freeman, Walter J