Biodegradable fibrous scaffolds with tunable properties formed from photo-cross-linkable poly(glycerol sebacate).
Biodegradable fibrous scaffolds with tunable properties formed from photo-cross-linkable poly(glycerol sebacate).
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DOI：
10.1021/am900403k
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发表时间：
2009-09
影响因子：
9.5
通讯作者：
Burdick, Jason A.
中科院分区：
文献类型：
--
作者：
Ifkovits, Jamie L.;Devlin, Jeffrey J.;Eng, George;Martens, Timothy P.;Vunjak-Novakovic, Gordana;Burdick, Jason A.
越来越明显的是，支架的结构和机械性能，特别是在模仿自然组织的特征方面，对组织工程的应用是重要的。丙烯酸酯聚甘油癸酸酯（Acr-PGS）是一种在紫外线照射下可以交联的材料，在Acr-PGS合成过程中，通过简单的改变就可以形成具有可调机械和降解性能的网络。例如，大分子上丙烯酸酯官能团的数量决定了最终网络中形成的交联的浓度。合成了三种高分子聚合物，它们形成的网络在拉伸模量（~30 kPa至6.6 MPa）和降解行为（~ 20%至100%的质量损失）方面变化很大，这是基于丙烯酸化程度（~1至24%）。以明胶为载体聚合物促进纤维形成和细胞粘附，利用静电纺丝技术将这些高分子聚合物加工成可生物降解的纤维支架。所得到的支架在力学（拉伸模量从~60 kPa到1 MPa）和降解（12周后质量损失~ 45%到70%）方面也各不相同。间充质干细胞在所有纤维支架上的粘附和增殖与对照组没有区别。在大鼠急性心肌梗死模型中，支架植入心脏表面显示出类似的多样性，并且在宿主反应中显示出支架厚度和化学成分的依赖性。总之，这些不同的支架具有可定制的化学、结构、机械和降解性能，在广泛的软组织工程中具有潜在的用途。
It is becoming increasingly apparent that the architecture and mechanical properties of scaffolds, particularly with respect to mimicking features of natural tissues, are important for tissue engineering applications. Acrylated poly(glycerol sebacate) (Acr-PGS) is a material that can be crosslinked upon exposure to ultraviolet light, leading to networks with tunable mechanical and degradation properties through simple changes during Acr-PGS synthesis. For example, the number of acrylate functional groups on the macromer dictates the concentration of crosslinks formed in the resulting network. Three macromers were synthesized that form networks that vary dramatically with respect to their tensile modulus (~30 kPa to 6.6 MPa) and degradation behavior (~20 to 100% mass loss at 12 weeks) based on the extent of acrylation (~1 to 24%). These macromers were processed into biodegradable fibrous scaffolds using electrospinning, with gelatin as a carrier polymer to facilitate fiber formation and cell adhesion. The resulting scaffolds were also diverse with respect to their mechanics (tensile modulus ranging from ~60 kPa to 1 MPa) and degradation (~45 to 70% mass loss by 12 weeks). Mesenchymal stem cell adhesion and proliferation on all fibrous scaffolds was indistinguishable from controls. The scaffolds showed similar diversity when implanted on the surface of hearts in a rat model of acute myocardial infarction and demonstrated a dependence on scaffold thickness and chemistry in the host response. In summary, these diverse scaffolds with tailorable chemical, structural, mechanical and degradation properties are potentially useful for the engineering of a wide range of soft tissues.
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影响因子：
2.1
作者：
Godier, Amandine F. G.;Marolt, Darja;Vunjak-Novakovic, Gordana
通讯作者：
Vunjak-Novakovic, Gordana
影响因子：
4.6
作者：
Shin, YM;Hohman, MM;Rutledge, GC
通讯作者：
Rutledge, GC
DOI：
10.1002/jbm.10204
发表时间：
2002-09-05
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
Guan, JJ;Sacks, MS;Wagner, WR
通讯作者：
Wagner, WR
影响因子：
9.7
作者：
Chong, E. J.;Phan, T. T.;Lim, C. T.
通讯作者：
Lim, C. T.
影响因子：
4.9
作者：
Khademhosseini, Ali;Eng, George;Burdick, Jason A.
通讯作者：
Burdick, Jason A.