Function-based intersubject alignment of human cortical anatomy.

Function-based intersubject alignment of human cortical anatomy.
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基于功能的人体皮质解剖结构。

DOI:
10.1093/cercor/bhp085
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发表时间:
2010-01
期刊:
Cerebral cortex (New York, N.Y. : 1991)
影响因子:
--
通讯作者:
Haxby JV
Haxby JV
中科院分区:
其他
文献类型:
--
作者:
Sabuncu MR;Singer BD;Conroy B;Bryan RE;Ramadge PJ;Haxby JV

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要得出有关人脑功能神经解剖结构的结论,需要将个体大脑的功能解剖结构与群体变异性联系起来的方法。我们开发了一种方法,根据观看电影引发的神经活动模式来调整个体大脑的功能神经解剖结构。对齐不是基于功能定义的区域(其位置被定义为质心或局部最大响应)进行对齐,而是基于响应模式,因为它们在皮质区域内和皮质区域之间进行空间分布。该方法是在膨胀的球形皮质表面的二维流形中实现的。该方法虽然是使用电影数据开发的,但成功地推广到通过另一种认知激活范式(查看物体和面部的静态图像)获得的数据,并改进了该实验中通过标准广义线性模型(GLM)分析测量的群体统计数据。
Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method for aligning the functional neuroanatomy of individual brains based on the patterns of neural activity that are elicited by viewing a movie. Instead of basing alignment on functionally defined areas, whose location is defined as the center of mass or the local maximum response, the alignment is based on patterns of response as they are distributed spatially both within and across cortical areas. The method is implemented in the two-dimensional manifold of an inflated, spherical cortical surface. The method, although developed using movie data, generalizes successfully to data obtained with another cognitive activation paradigm—viewing static images of objects and faces—and improves group statistics in that experiment as measured by a standard general linear model (GLM) analysis.
DOI: 10.1006/nimg.1998.0396
发表时间: 1999-02-01
期刊: NEUROIMAGE
影响因子: 5.7
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