Effect of Osteopathic Cranial Manipulative Medicine on an Aged Rat Model of Alzheimer Disease.
Effect of Osteopathic Cranial Manipulative Medicine on an Aged Rat Model of Alzheimer Disease.
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DOI：
10.7556/jaoa.2019.121
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发表时间：
2019-10-15
期刊：
影响因子：
--
通讯作者：
Costa BM
中科院分区：
文献类型：
--
作者：
Tobey H;Lucas T;Bledsoe D;Mykins M;Campbell C;Berr SS;Sasser T;Helm R;Brolinson PG;Klein BG;Costa BM
在衰老的大脑中，脑血管和液体循环的脉动减少导致不同隔室之间的液体交换受损，这为导致阿尔茨海默病（AD）的神经炎症奠定了基础。中枢神经系统的淋巴管在脑源性代谢废物的清除中发挥作用，这一认识为增加大分子（如β淀粉样蛋白）的清除提供了前所未有的能力。然而，目前还没有药物机制可以增加老化大脑中的液体循环。利用自然衰老的AD大鼠模型，证明骨疗法颅推拿（OCMM）技术，特别是第四脑室的压缩，对空间记忆的影响，以及与中枢神经系统代谢废物清除机制相关的底物的变化。经过7天的OCMM治疗，6只大鼠的空间记忆有显著改善。活体动物正电子发射断层成像和免疫分析显示，OCMM降低了老年大鼠脑中的β淀粉样蛋白水平，激活了星形胶质细胞，并改善了神经传递。这些发现揭示了老年大鼠OCMM的分子机制。这项研究和进一步的调查将帮助医生推广OCMM作为AD患者的循证辅助治疗。
In the aging brain, reduction in the pulsation of cerebral vasculature and fluid circulation causes impairment in the fluid exchange between different compartments and lays a foundation for the neuroinflammation that results in Alzheimer disease (AD). The knowledge that lymphatic vessels in the central nervous system play a role in the clearance of brain-derived metabolic waste products opens an unprecedented capability to increase the clearance of macromolecules such as amyloid β proteins. However, currently there is no pharmacologic mechanism available to increase fluid circulation in the aging brain. To demonstrate the influence of an osteopathic cranial manipulative medicine (OCMM) technique, specifically, compression of the fourth ventricle, on spatial memory and changes in substrates associated with mechanisms of metabolic waste clearance in the central nervous system using the naturally aged rat model of AD. Significant improvement was found in spatial memory in 6 rats after 7 days of OCMM sessions. Live animal positron emission tomographic imaging and immunoassays revealed that OCMM reduced amyloid β levels, activated astrocytes, and improved neurotransmission in the aged rat brains. These findings demonstrate the molecular mechanism of OCMM in aged rats. This study and further investigations will help physicians promote OCMM as an evidence-based adjunctive treatment for patients with AD.
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影响因子：
4.8
作者：
Nie, Binbin;Chen, Kewei;Zhao, Shujun;Liu, Junhua;Gu, Xiaochun;Yao, Qunli;Hui, Jiaojie;Zhang, Zhijun;Teng, Gaojun;Zhao, Chunjie;Shan, Baoci
通讯作者：
Shan, Baoci
影响因子：
1.4
作者：
Creasy, Caitlin;Schander, Artur;Hodge, Lisa M.
通讯作者：
Hodge, Lisa M.
影响因子：
3.5
作者：
Mulcahy, Jane;Vaughan, Brett
通讯作者：
Vaughan, Brett
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
1.4
作者：
Huff, Jamie B.;Schander, Artur;Hodge, Lisa M.
通讯作者：
Hodge, Lisa M.