Aerobic exercise training reduces cannabis craving and use in non-treatment seeking cannabis-dependent adults.
Aerobic exercise training reduces cannabis craving and use in non-treatment seeking cannabis-dependent adults.
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DOI：
10.1371/journal.pone.0017465
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发表时间：
2011-03-08
期刊：
影响因子：
3.7
通讯作者：
Martin PR
中科院分区：
文献类型：
--
作者：
Buchowski MS;Meade NN;Charboneau E;Park S;Dietrich MS;Cowan RL;Martin PR
大麻依赖是一个重大的公共卫生问题。因为没有批准的药物治疗这种情况，治疗必须依靠行为方法，经验上辅之以运动等生活方式的改变。研究在正常生活条件下，适度有氧运动对大麻依赖成年人的大麻渴望和使用的影响。参与者在2周内参加了10次有监督的30分钟跑步机运动，这些跑步机运动使用心率（HR）监测（60-70% HR储备）进行标准化。运动课程由运动生理学家在医疗监督下进行。久坐或最低限度活动的非寻求治疗的大麻依赖成年人（n = 12，年龄25±3岁，8名女性）符合使用DSM-IV（SCID）结构化临床访谈的物质滥用模块的原发性大麻依赖标准。 在研究前1周、研究期间和研究后2周评估自我报告的药物使用情况。参与者在运动前后查看视觉大麻线索，并使用Mariobox渴望问卷（MCQ-SF）评估主观大麻渴望。导入期内的每日大麻使用量为每天5.9个关节（SD = 3.1，范围1.8-10.9）。 运动（2.8个关节，SD = 1.6，范围0.9-5.4）和随访（4.1个关节，SD = 2.5，范围1.1-9.5）期间的平均大麻使用水平低于磨合期（均P<.005）。 运动前和运动后渴望评估的平均MCQ因子得分在强迫性（P = 0.006）、情绪性（P = 0.002）、期望（P = 0.002）和目的性（P = 0.002）方面有所降低。 这项试点研究的结果保证了更大的，足够有力的对照试验，以测试规定的适度有氧运动作为大麻依赖治疗的一部分的疗效。解释大麻使用这些有益影响的神经生物学机制可能会导致对大麻依赖的身体和情感基础的理解，并从这种疾病中恢复。ClinicalTrials.gov NCT00838448]
Cannabis dependence is a significant public health problem. Because there are no approved medications for this condition, treatment must rely on behavioral approaches empirically complemented by such lifestyle change as exercise. To examine the effects of moderate aerobic exercise on cannabis craving and use in cannabis dependent adults under normal living conditions. Participants attended 10 supervised 30-min treadmill exercise sessions standardized using heart rate (HR) monitoring (60–70% HR reserve) over 2 weeks. Exercise sessions were conducted by exercise physiologists under medical oversight. Sedentary or minimally active non-treatment seeking cannabis-dependent adults (n = 12, age 25±3 years, 8 females) met criteria for primary cannabis dependence using the Substance Abuse module of the Structured Clinical Interview for DSM-IV (SCID). Self-reported drug use was assessed for 1-week before, during, and 2-weeks after the study. Participants viewed visual cannabis cues before and after exercise in conjunction with assessment of subjective cannabis craving using the Marijuana Craving Questionnaire (MCQ-SF). Daily cannabis use within the run-in period was 5.9 joints per day (SD = 3.1, range 1.8–10.9). Average cannabis use levels within the exercise (2.8 joints, SD = 1.6, range 0.9–5.4) and follow-up (4.1 joints, SD = 2.5, range 1.1–9.5) periods were lower than during the run-in period (both P<.005). Average MCQ factor scores for the pre- and post-exercise craving assessments were reduced for compulsivity (P = .006), emotionality (P = .002), expectancy (P = .002), and purposefulness (P = .002). The findings of this pilot study warrant larger, adequately powered controlled trials to test the efficacy of prescribed moderate aerobic exercise as a component of cannabis dependence treatment. The neurobiological mechanisms that account for these beneficial effects on cannabis use may lead to understanding of the physical and emotional underpinnings of cannabis dependence and recovery from this disorder. ClinicalTrials.gov NCT00838448]
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影响因子：
2.3
作者：
Cowan, Ronald L.;Bolo, Nicolas R.;Renshaw, Perrv F.
通讯作者：
Renshaw, Perrv F.
DOI：
10.1046/j.1365-201x.1997.00118.x
发表时间：
1997-04-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
Meeusen, R;Smolders, I;Michotte, Y
通讯作者：
Michotte, Y
影响因子：
4.2
作者：
Fisher, BE;Petzinger, GM;Jakowec, MW
通讯作者：
Jakowec, MW
影响因子：
5.5
作者：
Dunn, AL;Trivedi, MH;Chambliss, HO
通讯作者：
Chambliss, HO
影响因子：
3.6
作者：
Cowan, Ronald L.;Joers, James M.;Dietrich, Mary S.
通讯作者：
Dietrich, Mary S.