Sex Modulates the Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment.
Sex Modulates the Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment.
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DOI：
10.3389/fpsyt.2022.804168
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发表时间：
2022
影响因子：
4.7
通讯作者：
Cordes, Dietmar
中科院分区：
文献类型：
--
作者：
Yang, Zhengshi;Caldwell, Jessica Z. K.;Cummings, Jeffrey L.;Ritter, Aaron;Kinney, Jefferson W.;Cordes, Dietmar
关键词：
评估病理老化对轻度认知障碍（MCI）参与者尾状核功能连接的影响，并研究性别和淀粉样蛋白是否以及如何促成这一过程。在我们的分析中，包括来自163名认知正常（CN）老年人的277次功能性磁共振成像（fMRI）和来自139名MCI参与者的309次功能性磁共振成像（fMRI）作为主要样本。Pearson相关性用于表征尾状核与每个脑区域之间的功能连接（FC），然后计算尾状核结强度以量化整体尾状核FC强度。尾状结强度与年龄之间的关联分析分别在MCI和CN中使用线性混合效应（LME）模型进行，协变量为（教育，利手，性别，载脂蛋白E4，和受试者内效应）。使用具有淀粉样蛋白状态的fMRI数据子集进行协方差分析，以研究性别、淀粉样蛋白状态及其对衰老的相互作用影响。LME模型分别应用于MCI组中的女性和男性，以评估尾状核结强度和每个区域与尾状核的连接的老化效应。然后，我们评估了性别和淀粉样蛋白状态在神经心理学评分与年龄或尾状结强度相关性中的作用。一个独立的队列被用来验证MCI中的性别依赖性衰老效应。MCI组与CN组相比，尾状结强度的年龄相关性增加显著更强。对女性和男性分别进行分析发现，MCI参与者中尾状核强度的年龄效应仅对女性有显著影响（左：P = 6.23 × 10−7，右：P = 3.37 × 10−8），但对男性无显著影响（双侧尾状核P > 0.3）。脑淀粉样蛋白负荷对尾状结强度的增龄效应没有显著的介导作用。尾状核与腹侧前额叶皮质的连接性对MCI女性尾状核节点强度的衰老效应有显著影响。更高的尾状结强度与MCI女性的认知能力差显著相关，但与男性无关。无论淀粉样蛋白状态如何，性别调节病理老化对MCI中尾状结强度的影响。尾状核淋巴结强度可能是MCI妇女病理老化的敏感生物标志物。
To assess the pathological aging effect on caudate functional connectivity among mild cognitive impairment (MCI) participants and examine whether and how sex and amyloid contribute to this process. Two hundred and seventy-seven functional magnetic resonance imaging (fMRI) sessions from 163 cognitive normal (CN) older adults and 309 sessions from 139 participants with MCI were included as the main sample in our analysis. Pearson's correlation was used to characterize the functional connectivity (FC) between caudate nuclei and each brain region, then caudate nodal strength was computed to quantify the overall caudate FC strength. Association analysis between caudate nodal strength and age was carried out in MCI and CN separately using linear mixed effect (LME) model with covariates (education, handedness, sex, Apolipoprotein E4, and intra-subject effect). Analysis of covariance was conducted to investigate sex, amyloid status, and their interaction effects on aging with the fMRI data subset having amyloid status available. LME model was applied to women and men separately within MCI group to evaluate aging effects on caudate nodal strength and each region's connectivity with caudate nuclei. We then evaluated the roles of sex and amyloid status in the associations of neuropsychological scores with age or caudate nodal strength. An independent cohort was used to validate the sex-dependent aging effects in MCI. The MCI group had significantly stronger age-related increase of caudate nodal strength compared to the CN group. Analyzing women and men separately revealed that the aging effect on caudate nodal strength among MCI participants was significant only for women (left: P = 6.23 × 10−7, right: P = 3.37 × 10−8), but not for men (P > 0.3 for bilateral caudate nuclei). The aging effects on caudate nodal strength were not significantly mediated by brain amyloid burden. Caudate connectivity with ventral prefrontal cortex substantially contributed to the aging effect on caudate nodal strength in women with MCI. Higher caudate nodal strength is significantly related to worse cognitive performance in women but not in men with MCI. Sex modulates the pathological aging effects on caudate nodal strength in MCI regardless of amyloid status. Caudate nodal strength may be a sensitive biomarker of pathological aging in women with MCI.
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影响因子：
4.2
作者：
Armstrong, Nicole M.;Huang, Chiung-Wei;Resnick, Susan M.
通讯作者：
Resnick, Susan M.
DOI：
10.1016/j.trci.2018.06.006
发表时间：
2018
期刊：
Alzheimer's & dementia (New York, N. Y.)
影响因子：
--
作者：
Miller JB;Cummings J;Nance C;Ritter A
通讯作者：
Ritter A
影响因子：
7.4
作者：
Li, Rena;Singh, Meharvan
通讯作者：
Singh, Meharvan
影响因子：
4.2
作者：
Backman, Lars;Karlsson, Sari;Nyberg, Lars
通讯作者：
Nyberg, Lars
影响因子：
16.2
作者：
Jagust W
通讯作者：
Jagust W