White matter tract signatures of the progressive aphasias.
White matter tract signatures of the progressive aphasias.
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DOI：
10.1016/j.neurobiolaging.2012.12.002
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发表时间：
2013-06
影响因子：
4.2
通讯作者：
Warren JD
中科院分区：
文献类型：
--
作者：
Mahoney CJ;Malone IB;Ridgway GR;Buckley AH;Downey LE;Golden HL;Ryan NS;Ourselin S;Schott JM;Rossor MN;Fox NC;Warren JD
原发性进行性失语症（PPA）是一组异质性的语言主导的神经退行性疾病，由大规模的脑网络退化引起。白色物质（WM）通路将网络结合在一起，因此可能包含有关PPA发病机制的信息。在这里，我们使用扩散张量成像和基于束的空间统计学比较33例PPA患者（13例非流利/语法不清PPA），10例逻辑缺失变体PPA和10例语义变体PPA的PPA综合征之间的WM束变化，以及阿尔茨海默病和健康对照。非流利/语法缺失型PPA主要与左侧和前束改变相关，包括钩束（UF）和皮质下投射;语义变异型PPA伴双侧下纵束和UF改变;以及逻辑缺失型PPA伴双侧但主要是左侧下纵束、UF、上级纵束和皮质下投射改变。道改变比灰质改变更广泛，并且在扩散率指标之间跨道和PPA综合征的改变程度不同。PPA综合征的这些WM特征说明了这些疾病中大脑语言网络的选择性脆弱性，并且可能具有某些病理特异性。
The primary progressive aphasias (PPA) are a heterogeneous group of language-led neurodegenerative diseases resulting from large-scale brain network degeneration. White matter (WM) pathways bind networks together, and might therefore hold information about PPA pathogenesis. Here we used diffusion tensor imaging and tract-based spatial statistics to compare WM tract changes between PPA syndromes and with respect to Alzheimer's disease and healthy controls in 33 patients with PPA (13 nonfluent/agrammatic PPA); 10 logopenic variant PPA; and 10 semantic variant PPA. Nonfluent/agrammatic PPA was associated with predominantly left-sided and anterior tract alterations including uncinate fasciculus (UF) and subcortical projections; semantic variant PPA with bilateral alterations in inferior longitudinal fasciculus and UF; and logopenic variant PPA with bilateral but predominantly left-sided alterations in inferior longitudinal fasciculus, UF, superior longitudinal fasciculus, and subcortical projections. Tract alterations were more extensive than gray matter alterations, and the extent of alteration across tracts and PPA syndromes varied between diffusivity metrics. These WM signatures of PPA syndromes illustrate the selective vulnerability of brain language networks in these diseases and might have some pathologic specificity.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
5.3
作者：
Awad, Malaka;Warren, Jane E.;Wise, Richard J. S.
通讯作者：
Wise, Richard J. S.
影响因子：
38.1
作者：
Grossman, Murray
通讯作者：
Grossman, Murray
影响因子：
14.5
作者：
Acosta-Cabronero, Julio;Patterson, Karalyn;Nestor, Peter J.
通讯作者：
Nestor, Peter J.
影响因子：
2.4
作者：
Larsson, EM;Englund, E;Brockstedt, S
通讯作者：
Brockstedt, S