Characterising patterns of COVID-19 and long COVID symptoms: evidence from nine UK longitudinal studies.
Characterising patterns of COVID-19 and long COVID symptoms: evidence from nine UK longitudinal studies.
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DOI：
10.1007/s10654-022-00962-6
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发表时间：
2023-03
影响因子：
13.6
通讯作者：
CONVALESCENCE Study
中科院分区：
文献类型：
--
作者：
Bowyer, Ruth C. E.;Huggins, Charlotte;Toms, Renin;Shaw, Richard J. J.;Hou, Bo;Thompson, Ellen J. J.;Kwong, Alex S. F.;Williams, Dylan M. M.;Kibble, Milla;Ploubidis, George B. B.;Timpson, Nicholas J. J.;Sterne, Jonathan A. C.;Chaturvedi, Nishi;Steves, Claire J. J.;Tilling, Kate;Silverwood, Richard J. J.;CONVALESCENCE Study
针对全球人群的多项研究已经确定了2019年冠状病毒病（COVID-19）和长期COVID的主要症状。然而，由于在没有COVID-19的情况下也可能出现症状，因此缺乏适当的控制通常意味着无法检查症状对急性COVID-19或长期COVID的特异性，以及COVID-19后症状升高的程度和时间长度。我们分析了9项英国纵向研究中COVID-19和长期COVID症状的个体症状患病率和特征模式，共计42，000多名参与者。在三个组（“无COVID-19”，“过去12周内COVID-19”，“COVID-19 > 12周前”）中分别进行潜在类别分析，数据不支持每组中存在两种以上不同的症状模式，代表高和低症状负担。比较“过去12周内感染COVID-19”和“无COVID-19”组之间的高症状负担类别，我们确定了急性COVID-19的特征性症状，包括味觉和嗅觉丧失、疲劳、咳嗽、呼吸急促和肌肉疼痛或疼痛。比较“COVID-19 > 12周前”和“无COVID-19”组之间的高症状负担类别，我们发现了长期COVID的特征性症状，包括疲劳、呼吸急促、肌肉疼痛或疼痛、难以集中注意力和胸闷。在COVID-19 > 12周前的个体中确定的症状模式与自我报告的因COVID-19症状而无法正常工作的时间长度密切相关，这表明确定的症状模式对应于长期COVID。建立关于典型的长期COVID症状的证据基础将改善对这种疾病的诊断，并提高引出潜在生物机制的能力，从而使患者更好地获得治疗和服务。在线版本包含补充材料，可通过10.1007/s10654-022-00962-6获得。
Multiple studies across global populations have established the primary symptoms characterising Coronavirus Disease 2019 (COVID-19) and long COVID. However, as symptoms may also occur in the absence of COVID-19, a lack of appropriate controls has often meant that specificity of symptoms to acute COVID-19 or long COVID, and the extent and length of time for which they are elevated after COVID-19, could not be examined. We analysed individual symptom prevalences and characterised patterns of COVID-19 and long COVID symptoms across nine UK longitudinal studies, totalling over 42,000 participants. Conducting latent class analyses separately in three groups (‘no COVID-19’, ‘COVID-19 in last 12 weeks’, ‘COVID-19 > 12 weeks ago’), the data did not support the presence of more than two distinct symptom patterns, representing high and low symptom burden, in each group. Comparing the high symptom burden classes between the ‘COVID-19 in last 12 weeks’ and ‘no COVID-19’ groups we identified symptoms characteristic of acute COVID-19, including loss of taste and smell, fatigue, cough, shortness of breath and muscle pains or aches. Comparing the high symptom burden classes between the ‘COVID-19 > 12 weeks ago’ and ‘no COVID-19’ groups we identified symptoms characteristic of long COVID, including fatigue, shortness of breath, muscle pain or aches, difficulty concentrating and chest tightness. The identified symptom patterns among individuals with COVID-19 > 12 weeks ago were strongly associated with self-reported length of time unable to function as normal due to COVID-19 symptoms, suggesting that the symptom pattern identified corresponds to long COVID. Building the evidence base regarding typical long COVID symptoms will improve diagnosis of this condition and the ability to elicit underlying biological mechanisms, leading to better patient access to treatment and services. The online version contains supplementary material available at 10.1007/s10654-022-00962-6.
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影响因子：
15.1
作者：
Iqbal FM;Lam K;Sounderajah V;Clarke JM;Ashrafian H;Darzi A
通讯作者：
Darzi A
影响因子：
5.2
作者：
Cheng X;Wan H;Yuan H;Zhou L;Xiao C;Mao S;Li Z;Hu F;Yang C;Zhu W;Zhou J;Zhang T
通讯作者：
Zhang T
DOI：
10.1016/j.jinf.2021.01.004
发表时间：
2021-03
期刊：
The Journal of infection
影响因子：
--
作者：
Moreno-Pérez O;Merino E;Leon-Ramirez JM;Andres M;Ramos JM;Arenas-Jiménez J;Asensio S;Sanchez R;Ruiz-Torregrosa P;Galan I;Scholz A;Amo A;González-delaAleja P;Boix V;Gil J;COVID19-ALC research group
通讯作者：
COVID19-ALC research group
影响因子：
13.6
作者：
Caspersen IH;Magnus P;Trogstad L
通讯作者：
Trogstad L
DOI：
10.7759/cureus.13080
发表时间：
2021-02-02
期刊：
Cureus
影响因子：
--
作者：
Iqbal A;Iqbal K;Arshad Ali S;Azim D;Farid E;Baig MD;Bin Arif T;Raza M
通讯作者：
Raza M