Replacement of tibialis cranialis tendon with polyester, silicone-coated artificial tendon preserves biomechanical function in rabbits compared to tendon excision only.
Replacement of tibialis cranialis tendon with polyester, silicone-coated artificial tendon preserves biomechanical function in rabbits compared to tendon excision only.
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DOI：
10.1186/s13018-024-04581-7
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发表时间：
2024-02-02
影响因子：
2.6
通讯作者：
Crouch DL
中科院分区：
文献类型：
--
作者：
Easton KL;Hatch C;Stephens K;Marler D;Fidelis O;Sun X;Bowers KM;Billings C;Greenacre CB;Anderson DE;Crouch DL
人工腱可能是修复严重肌腱缺损的一种有效的替代自体和同种异体肌腱移植的方法。这项研究的目的是量化在活体后肢生物力学(地面接触压力和矢状面运动)在跳跃步态中，兔的胫骨颅肌肌腱严重缺损处，使用或不使用人工肌腱修复。在5只兔中，用聚酯硅胶涂层人工腱(PET-SI)替换左后肢的胫骨肌腱，5只手术对照兔在没有置换(TE)的情况下，完全切除左后肢的生物胫骨肌腱。术后8周，TE组左后肢最大垂直地面接触力较术前显著降低(p = 0.0215)。统计参数图分析显示，与基线相比，TE组在术后2周的站立状态和术后2周和8周的大步摆动阶段膝关节伸展程度显著高于基线(p <； 0.05)。此外，在术后2周和8周，TE组的踝关节在摆动时的踝关节屈曲程度显著高于TE组(p <； 0.05)。相比之下，在PET-SI组中，膝关节或脚踝的SPM分析在不同的时间点上没有显著差异。我们的研究结果表明，人工胫骨颅肌肌腱有效地替代了天然肌腱的生物力学功能。未来的研究应该调查(1)人工肌腱对其他(如神经肌肉)组织和系统的影响，以及(2)肌腱损伤和人工肌腱植入之间存在延迟时的生物力学结果。网上版载有补充材料，可在10.1186/s13018-024-04581-7查阅。
Artificial tendons may be an effective alternative to autologous and allogenic tendon grafts for repairing critically sized tendon defects. The goal of this study was to quantify the in vivo hindlimb biomechanics (ground contact pressure and sagittal-plane motion) during hopping gait of rabbits having a critically sized tendon defect of the tibialis cranialis and either with or without repair using an artificial tendon. In five rabbits, the tibialis cranialis tendon of the left hindlimb was surgically replaced with a polyester, silicone-coated artificial tendon (PET-SI); five operated control rabbits underwent complete surgical excision of the biological tibialis cranialis tendon in the left hindlimb with no replacement (TE). At 8 weeks post-surgery, peak vertical ground contact force in the left hindlimb was statistically significantly less compared to baseline for the TE group (p = 0.0215). Statistical parametric mapping (SPM) analysis showed that, compared to baseline, the knee was significantly more extended during stance at 2 weeks post-surgery and during the swing phase of stride at 2 and 8 weeks post-surgery for the TE group (p < 0.05). Also, the ankle was significantly more plantarflexed during swing at 2 and 8 weeks postoperative for the TE group (p < 0.05). In contrast, there were no significant differences in the SPM analysis among timepoints in the PET-SI group for the knee or ankle. Our findings suggest that the artificial tibialis cranialis tendon effectively replaced the biomechanical function of the native tendon. Future studies should investigate (1) effects of artificial tendons on other (e.g., neuromuscular) tissues and systems and (2) biomechanical outcomes when there is a delay between tendon injury and artificial tendon implantation. The online version contains supplementary material available at 10.1186/s13018-024-04581-7.
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DOI：
10.1016/j.biocel.2013.06.011
发表时间：
2013-10
影响因子：
4
作者：
Bodine, Sue C.
通讯作者：
Bodine, Sue C.
影响因子：
4.6
作者：
Hast MW;Zuskov A;Soslowsky LJ
通讯作者：
Soslowsky LJ
影响因子：
25
作者：
Mathis, Alexander;Mamidanna, Pranav;Bethge, Matthias
通讯作者：
Bethge, Matthias
影响因子：
2.8
作者：
Melvin, Alan;Litsky, Alan;Mayerson, Joel;Witte, David;Melvin, David;Juncosa-Melvin, Natalia
通讯作者：
Juncosa-Melvin, Natalia
影响因子：
2.4
作者：
Hall，Patrick T.;Stubbs，Caleb;Crouch，Dustin L.
通讯作者：
Crouch，Dustin L.