Prenatal nitrate air pollution exposure and reduced child lung function: Timing and fetal sex effects.
Prenatal nitrate air pollution exposure and reduced child lung function: Timing and fetal sex effects.
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DOI：
10.1016/j.envres.2018.08.019
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发表时间：
2018-11
影响因子：
8.3
通讯作者：
Wright RJ
中科院分区：
文献类型：
--
作者：
Bose S;Rosa MJ;Mathilda Chiu YH;Leon Hsu HH;Di Q;Lee A;Kloog I;Wilson A;Schwartz J;Wright RO;Morgan WJ;Coull BA;Wright RJ
Prenatal particulate air pollution exposure may alter lung growth and development in utero in a time-sensitive and sex-specific manner, resulting in reduced lung function in childhood. Such relationships have not been examined for nitrate (NO3−). We implemented Bayesian distributed lag interaction models (BDLIMs) to identify sensitive prenatal windows for the influence of NO3− on lung function at age 7 years, assessing effect modification by fetal sex. Analyses included 191 mother-child dyads. Daily ambient NO3− exposure over pregnancy was estimated using a hybrid chemical transport (Geos-Chem)/land-use regression model. Spirometry was performed at mean (SD) age of 6.99 (0.89) years, with forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) z-scores accounting for child age, sex, height and race/ethnicity. Most mothers were Hispanic (65%) or Black (22%), had ≤ high school education (67%), and never smoked (71%); 17% children had asthma. BDILMs adjusted for maternal age and education and child’s asthma identified an early sensitive window of 6-12 weeks gestation, during which increased NO3− was significantly associated with reduced FEV1 z-scores specifically among boys. BDLIM analyses demonstrated similar sex-specific patterns for FVC. Early gestational NO3− exposure is associated with reduced child lung function, especially in boys.
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影响因子：
11.8
作者：
Laurent O;Hu J;Li L;Kleeman MJ;Bartell SM;Cockburn M;Escobedo L;Wu J
通讯作者：
Wu J
影响因子：
5.9
作者：
Lee, Alison G.;Chiu, Yueh-Hsiu M.;Wright, Rosalind J.
通讯作者：
Wright, Rosalind J.
DOI：
10.1152/ajplung.00047.2016
发表时间：
2016-08-01
影响因子：
4.9
作者：
Lingappan, Krithika;Jiang, Weiwu;Moorthy, Bhagavatula
通讯作者：
Moorthy, Bhagavatula
影响因子：
24.3
作者：
Latzin, P.;Roeoesli, M.;Frey, U.
通讯作者：
Frey, U.
影响因子：
8.3
作者：
Jedrychowski, Wieslaw;Perera, Frederica;Mrozek-Budzyn, Dorota;Mroz, Elzbieta;Flak, Elzbieta;Spengler, Jack D.;Edwards, Susan;Jacek, Ryszard;Kaim, Irena;Skolicki, Zbigniew
通讯作者：
Skolicki, Zbigniew