Association of blood lactate with carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
Association of blood lactate with carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
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DOI：
10.1016/j.atherosclerosis.2013.02.014
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发表时间：
2013-05
期刊：
影响因子：
5.3
通讯作者：
Young, J. Hunter
中科院分区：
文献类型：
--
作者：
Shantha, Ghanshyam Palamaner Subash;Wasserman, Bruce;Astor, Brad C.;Coresh, Josef;Brancati, Fredrick;Sharrett, A. Richey;Young, J. Hunter
心血管危险因素如衰老、吸烟、胰岛素抵抗等可能通过多种机制导致动脉粥样硬化，与线粒体功能障碍的关联可能是其中之一。为了检验这一假设，我们评估了血乳酸水平升高（线粒体功能障碍的标志）与颈动脉粥样硬化之间的关系。从社区颈动脉粥样硬化风险MRI研究的2066名参与者中，1496名被纳入本分析。使用钆增强MRI测量壁厚和脂质核的存在。血乳酸被分为四分位数（Q1: < 5.9 mg/dl, Q2: 5.9 - 7.2mg/dl, Q3: 7.3 - 9.2 mg/dl, Q4: >9.2 mg/dl）。在1496名研究参与者中，763名（51%）是女性，296名（19.8%）是非裔美国人，539名（36%）肥胖，308名（20.6%）患有糖尿病。乳酸和壁厚之间有很强的分级关联[Q1: 1.08 mm (95% CI: 1.01 mm - 1.15 mm), Q2: 1.33 mm (95% CI: 1.19 mm - 1.47 mm), Q3: 1.44 （95% CI: 1.34 mm - 1.54 mm）和Q4: 1.62 (95% CI: 1.53 mm - 1.71 mm)；在调整了年龄、性别、种族、身高、体重指数（BMI）、腰围、低密度脂蛋白（LDL）、高敏C反应蛋白（HsCRP）、他汀类药物使用、噻唑二酮使用、高血压和糖尿病等因素后，p（趋势<0.001）。在调整胰岛素抵抗标记物甘油三酯/高密度脂蛋白比值后，这种关联减弱，但仍然显著，[Q1: 0.96 mm (95% CI: 0.82 mm - 1.10 mm), Q2: 1.17 mm (95% CI: 1.08 mm - 1.26 mm), Q3: 1.18 mm (95% CI: 1.07 mm - 1.29 mm), Q4: 1.22 mm (95% CI: 1.13 mm - 1.31 mm)， p为线性趋势0.039]。在调整壁厚后，乳酸与脂质核心的存在没有关联。血乳酸与颈动脉粥样硬化有关。与甘油三酯/高密度脂蛋白比值（胰岛素抵抗的标志）调节的关联减弱，提示乳酸与颈动脉粥样硬化的关联可能与胰岛素抵抗有关。
Cardiovascular risk factors such as aging, smoking, and insulin resistance may lead to atherosclerosis through various mechanisms of which their association with mitochondrial dysfunction may be one of them. In order to examine this hypothesis, we assessed the association between elevated blood lactate, a marker of mitochondrial dysfunction, and carotid atherosclerosis. From a total of 2066 participants from the Atherosclerosis Risk In Communities Carotid MRI study, 1496 were included for this analysis. Wall Thickness and Lipid core presence were measured using gadolinium-enhanced MRI. Blood lactate was categorized into quartiles (Q1: < 5.9 mg/dl, Q2: 5.9 to 7.2mg/dl, Q3: 7.3 to 9.2 mg/dl, and Q4: >9.2 mg/dl). Of the 1496 study participants, 763 (51%) were females, 296 (19.8%) African American, 539 (36%) obese and 308 (20.6%) had diabetes. There was a strong and graded association between lactate and wall thickness [Q1: 1.08 mm (95% CI: 1.01 mm – 1.15 mm), Q2: 1.33 mm (95% CI: 1.19 mm – 1.47 mm), Q3: 1.44 (95% CI: 1.34 mm – 1.54 mm) and Q4: 1.62 (95% CI: 1.53 mm – 1.71 mm); p for trend <0.001] after adjusting for age, gender, ethnicity, stature, body mass index (BMI), waist circumference, LDL, High sensitivity C reactive protein (HsCRP), statin use, thiazolodinedione use, hypertension, and diabetes. This association was attenuated, but still significant, after adjusting for a marker of insulin resistance, the triglyceride/HDL ratio, [Q1: 0.96 mm (95% CI: 0.82 mm – 1.10 mm), Q2: 1.17 mm (95% CI: 1.08 mm – 1.26 mm), Q3: 1.18 mm (95% CI: 1.07 mm – 1.29 mm), Q4: 1.22 mm (95% CI: 1.13 mm – 1.31 mm), p for linear trend 0.039]. There was no association of lactate with lipid core presence after adjustment for wall thickness. Blood lactate is associated with carotid atherosclerosis. Attenuation of the association with adjustment for triglyceride/HDL ratio, a marker of insulin resistance, suggests that lactate’s association with carotid atherosclerosis may be related to insulin resistance.
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DOI：
10.1073/pnas.1032913100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Patti, ME;Butte, AJ;Mandarino, LJ
通讯作者：
Mandarino, LJ
影响因子：
7.1
作者：
KELLEY, DE;SLASKY, BS;JANOSKY, J
通讯作者：
JANOSKY, J
影响因子：
15.9
作者：
Morino, K;Petersen, KF;Shulman, GI
通讯作者：
Shulman, GI
影响因子：
5
作者：
HEISS, G;SHARRETT, AR;ALZOLA, C
通讯作者：
ALZOLA, C
影响因子：
4.2
作者：
BARHAM, D;TRINDER, P
通讯作者：
TRINDER, P