Electroacupuncture improves neuropathic pain: Adenosine, adenosine 5'-triphosphate disodium and their receptors perhaps change simultaneously.
Electroacupuncture improves neuropathic pain: Adenosine, adenosine 5'-triphosphate disodium and their receptors perhaps change simultaneously.
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DOI：
10.3969/j.issn.1673-5374.2012.33.007
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发表时间：
2012-11-25
影响因子：
6.1
通讯作者：
Du Y
中科院分区：
文献类型：
--
作者：
Ren W;Tu W;Jiang S;Cheng R;Du Y
通过针灸针向穴位施加刺激电流--被称为电针--有可能在人类受试者和实验动物身上产生镇痛作用。当在大鼠模型中应用针刺时，细胞外空间中的腺苷5 '-三磷酸二钠被分解为腺苷，腺苷反过来通过腺苷A1受体依赖性过程抑制疼痛传递。直接注射腺苷A1受体激动剂可增强针刺的镇痛作用。针刺的镇痛作用似乎是通过激活位于上行神经上的A1受体介导的。在神经病理性疼痛中，背根神经节神经元中存在P2 X嘌呤受体3（P2 X3）表达的上调。相反，当P2 X3受体表达下调时，机械性痛觉过敏的发作减少，并且建立的痛觉过敏显著逆转。电针似乎作用的途径与疼痛途径交织在一起，电针刺激与疼痛区域产生的脉冲会聚。电针可能通过同时作用于嘌呤能A1和P2 X3受体而对神经病理性疼痛产生镇痛作用。
Applying a stimulating current to acupoints through acupuncture needles – known as electroacupuncture – has the potential to produce analgesic effects in human subjects and experimental animals. When acupuncture was applied in a rat model, adenosine 5’-triphosphate disodium in the extracellular space was broken down into adenosine, which in turn inhibited pain transmission by means of an adenosine A1 receptor-dependent process. Direct injection of an adenosine A1 receptor agonist enhanced the analgesic effect of acupuncture. The analgesic effect of acupuncture appears to be mediated by activation of A1 receptors located on ascending nerves. In neuropathic pain, there is upregulation of P2X purinoceptor 3 (P2X3) receptor expression in dorsal root ganglion neurons. Conversely, the onset of mechanical hyperalgesia was diminished and established hyperalgesia was significantly reversed when P2X3 receptor expression was downregulated. The pathways upon which electroacupuncture appear to act are interwoven with pain pathways, and electroacupuncture stimuli converge with impulses originating from painful areas. Electroacupuncture may act via purinergic A1 and P2X3 receptors simultaneously to induce an analgesic effect on neuropathic pain.
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影响因子：
3.3
作者：
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通讯作者：
Hulsebosch, C. E.
影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.252537299
发表时间：
2002-12-24
影响因子：
11.1
作者：
Jarvis, MF;Burgard, EC;Faltynek, C
通讯作者：
Faltynek, C