Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management.
Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management.
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DOI：
10.3762/bjnano.12.24
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发表时间：
2021
影响因子：
3.1
通讯作者：
Akhtar N
中科院分区：
文献类型：
--
作者：
Awan UA;Raza A;Ali S;Saeed RF;Akhtar N
与癌症治疗相关的两个限制是抗癌药物的低功效和高剂量相关副作用。当前研究的目的是制造生物相容性多功能载药纳米级部分，用于联合治疗（化学光热疗法），具有最大功效和最小副作用。在此，我们报告了负载在涂有聚电解质聚（4-苯乙烯磺酸钠）（PSS-GNR）的金纳米棒上的阿霉素（DOX）在有或没有近红外激光（808 nm，功率密度= 1.5 W/cm2，持续2分钟）照射下的体外抗癌作用。 PSS-GNRs的载药量约为76%，载药量为3.2 mg DOX/mL。与未照射样品相比，激光照射后累积 DOX 释放量显着增加 (p < 0.05)。 GNR、PSS-GNR 和 DOX-PSS-GNR 的 zeta 电位值分别测量为 42 ± 0.1 mV、-40 ± 0.3 mV 和 39.3 ± 0.6 mV。 PSS-GNRs 纳米复合物被发现具有生物相容性，并表现出更高的光热稳定性。与没有激光照射的纳米复合物（65%）和单独使用阿霉素的纳米复合物（84%）相比，经过近红外激光照射的 DOX 缀合纳米复合物似乎更有效地抑制细胞（93%）。在激光照射下测得 PSS-GNRs-DOX 和 PSS-GNRs-DOX 的 IC50 值分别为 7.99 和 3.12 µg/mL。因此，基于化疗和光热策略的组合方法似乎是癌症管理中一个有前途的平台。
Two of the limitations associated with cancer treatment are the low efficacy and the high dose-related side effects of anticancer drugs. The purpose of the current study was to fabricate biocompatible multifunctional drug-loaded nanoscale moieties for co-therapy (chemo-photothermal therapy) with maximum efficacy and minimum side effects. Herein, we report in vitro anticancerous effects of doxorubicin (DOX) loaded on gold nanorods coated with the polyelectrolyte poly(sodium-4-styrenesulfonate) (PSS-GNRs) with and without NIR laser (808 nm, power density = 1.5 W/cm2 for 2 min) irradiation. The drug-loading capacity of PSS-GNRs was about 76% with a drug loading content of 3.2 mg DOX/mL. The cumulative DOX release significantly increased after laser exposure compared to non-irradiated samples (p < 0.05). The zeta potential values of GNRs, PSS-GNRs and DOX-PSS-GNRs were measured as 42 ± 0.1 mV, −40 ± 0.3 mV and 39.3 ± 0.6 mV, respectively. PSS-GNRs nanocomplexes were found to be biocompatible and showed higher photothermal stability. The DOX-conjugated nanocomplexes with NIR laser irradiation appear more efficient in cell inhibition (93%) than those without laser exposure (65%) and doxorubicin alone (84%). The IC50 values of PSS-GNRs-DOX and PSS-GNRs-DOX were measured as 7.99 and 3.12 µg/mL, respectively, with laser irradiation. Thus, a combinatorial approach based on chemotherapy and photothermal strategies appears to be a promising platform in cancer management.
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DOI：
10.3390/nano8040193
发表时间：
2018-03-27
期刊：
Nanomaterials (Basel, Switzerland)
影响因子：
--
作者：
Lu YJ;Lin PY;Huang PH;Kuo CY;Shalumon KT;Chen MY;Chen JP
通讯作者：
Chen JP
DOI：
10.1016/s1386-1425(01)00453-x
发表时间：
2001-08-01
影响因子：
4.4
作者：
Eliasson, C;Lorén, A;Abrahamsson, K
通讯作者：
Abrahamsson, K
用于组合光热/化疗和多模态成像的金盖帽磁芯/介孔二氧化硅壳纳米颗粒
影响因子：
14
作者：
Ma, Ming;Chen, Hangrong;Shi, Jianlin
通讯作者：
Shi, Jianlin
DOI：
10.1016/j.nano.2015.03.012
发表时间：
2015-08-01
影响因子：
5.4
作者：
Arunkumar, Pitchaimani;Raju, Baskar;Premkumar, Kumpati
通讯作者：
Premkumar, Kumpati
影响因子：
2.3
作者：
Awan, Uzma Azeem;Ali, Shaukat;Raza, Abida
通讯作者：
Raza, Abida