Season and sex have different effects on hematology and cytokines in striped hamsters (Cricetulus barabensis)
Season and sex have different effects on hematology and cytokines in striped hamsters (Cricetulus barabensis)
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季节和性别对条纹仓鼠（Cricetulus barabensis）的血液学和细胞因子有不同的影响
DOI：
10.1007/s00360-019-01246-4
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发表时间：
2019-11
影响因子：
2
通讯作者：
Hu Xiao-Kai
中科院分区：
文献类型：
--
作者：
Xu De-Li;Hu Xiao-Kai
温带动物面临着环境的季节性变化，因此它们的免疫反应也会发生季节性变化。在目前的研究中，血液学参数和细胞因子的季节性变化在条纹仓鼠（黑线仓鼠）进行了检查，以测试冬季免疫增强假说，即秋季和冬季的免疫功能往往比其他季节增加。雄性和雌性仓鼠是在2014年秋冬和2015年春夏从野外捕获的。雌雄仓鼠的最大体质量和雌性仓鼠的相对肥满度都出现在夏季，表明该季节的身体状况最好。雄性和雌性仓鼠的所有血液学参数均无差异，除中性粒细胞（GRAN）外，也不受季节和性别相互作用的影响。红细胞（RBC）和红细胞压积（PCV）在秋季和冬季高于春季和夏季，血红蛋白浓度（HGB）在冬季高于春季和夏季，表明仓鼠血液的携氧能力和氧亲和力在这些季节增加。与其他季节相比，白色细胞（WBC）数量冬季高于夏季，中性粒细胞（MID）、MID%、GRAN和GRAN %在冬季最高，均支持冬季免疫增强假说。然而，淋巴细胞计数（LYMF）是最高的春季，不符合这一假设。仓鼠的IL-2水平受季节、性别及其相互作用的影响，而TNF-α无此影响。无论性别，IL-4滴度在春季和夏季高于秋季和冬季的仓鼠。春季和夏季雄性仓鼠的INF-γ滴度无明显差异，而雌性仓鼠春季的INF-γ滴度低于冬季和夏季。在繁殖季节，较高的IL-2和IL-4水平可能对控制这些季节感染的可能性增加至关重要。总之，季节和性别对仓鼠不同的血液学特征和细胞因子水平有不同的影响。
Animals in the temperate zones face seasonal variations in environments and hence their immune responses change seasonally. In the current study, seasonal changes in hematological parameters and cytokines in striped hamsters (Cricetulus barabensis) were examined to test the winter immunoenhancement hypothesis, which states that immune function tends to increase in fall and winter compared with other seasons. Male and female hamsters were captured from the wild in the fall and winter of 2014 and in the spring and summer of 2015. Maximum body mass in both sexes and relative fatness in female hamsters occurred in the summer, indicating that body condition was the best during this season. All hematological parameters were not different between male and female hamsters, and were also not affected by the interaction of season and sex except neutrophil granulocytes (GRAN). Red blood cells (RBC) and haematocrit (PCV) were higher in the fall and winter, and hemoglobin concentration (HGB) was the highest in winter in hamsters compared with the spring and summer, implying that their oxygen-carrying capacity and oxygen affinity of the blood increased during these seasons. Compared with other seasons, the number of white blood cells (WBC) was higher in winter than in summer, intermediate granulocytes (MID), the percent of MID (MID%), GRAN and the percent of GRAN (GRAN%) were the highest in winter, which all supported the winter immunoenhancement hypothesis. However, the count of lymphocytes (LYMF) was the highest in spring, being inconsistent with this hypothesis. IL-2 levels, but not TNF-α, were influenced by seasons, sex and their interaction in hamsters. Regardless of sex, IL-4 titres were higher in spring and summer than in fall and winter in hamsters. INF-γ titres in male hamsters did not differ between the spring and summer, while its titres in female hamsters was lower in spring in contrast with winter and summer. Higher IL-2 and IL-4 levels during the breeding seasons might be crucial in controlling the increased possibilities of infections in these seasons. In summary, season and sex had disparate effects on different hematological profiles and the levels of cytokines in hamsters.
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影响因子：
24.1
作者：
Q. Lam;Liwei Lu
通讯作者：
Q. Lam;Liwei Lu
环境温度连续降低的条纹仓鼠的血清瘦素、能量预算和生热作用
影响因子：
1.6
作者：
Zhao, Zhi-Jun
通讯作者：
Zhao, Zhi-Jun
影响因子：
3.7
作者：
Zhao ZJ;Chi QS;Liu QS;Zheng WH;Liu JS;Wang DH
通讯作者：
Wang DH
影响因子：
1.3
作者：
A. Norte;A. Norte;J. Ramos;J. P. Sousa;B. Sheldon
通讯作者：
A. Norte;A. Norte;J. Ramos;J. P. Sousa;B. Sheldon
影响因子：
7.4
作者：
Stevenson, Tyler J.;Prendergast, Brian J.
通讯作者：
Prendergast, Brian J.