Photoperiodic time measurement and seasonal immunological plasticity.
Photoperiodic time measurement and seasonal immunological plasticity.
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DOI：
10.1016/j.yfrne.2014.10.002
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发表时间：
2015-04
影响因子：
7.4
通讯作者：
Prendergast, Brian J.
中科院分区：
文献类型：
--
作者：
Stevenson, Tyler J.;Prendergast, Brian J.
免疫力的季节性变化在自然界中很常见，白昼长度的变化足以引发许多脊椎动物免疫功能的增强和抑制。主要利用西伯利亚仓鼠的数据，本综述描述了哺乳动物免疫季节性变化的神经内分泌调节的形式和生理方面。光周期以性状特异性方式调节免疫，性腺激素分泌和甲状腺激素信号的季节性变化均参与季节性免疫调节。光周期驱动的仓鼠生殖和免疫系统的变化与碘甲状腺原氨酸脱碘酶介导的甲状腺激素信号的变化有关，但光周期对生殖神经内分泌和淋巴组织的表观遗传调控具有相反的作用。免疫能力的光周期变化可以解释自然界中疾病发病率和严重程度的年度变化的一部分，并提供一个有用的框架来帮助理解脑免疫相互作用。
Seasonal variations in immunity are common in nature, and changes in day length are sufficient to trigger enhancement and suppression of immune function in many vertebrates. Drawing primarily on data from Siberian hamsters, this review describes formal and physiological aspects of the neuroendocrine regulation of seasonal changes in mammalian immunity. Photoperiod regulates immunity in a trait-specific manner, and seasonal changes in gonadal hormone secretion and thyroid hormone signaling all participate in seasonal immunomodulation. Photoperiod-driven changes in the hamster reproductive and immune systems are associated with changes in iodothyronine deiodinase-mediated thyroid hormone signaling, but photoperiod exerts opposite effects on the epigenetic regulation of reproductive neuroendocrine and lymphoid tissues. Photoperiodic changes in immunocompetence may explain a proportion of the annual variance in disease incidence and severity in nature, and provide a useful framework to help understand brain-immune interactions.
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