Estimated acute effects of ambient ozone and nitrogen dioxide on mortality in the Pearl River Delta of southern China.
Estimated acute effects of ambient ozone and nitrogen dioxide on mortality in the Pearl River Delta of southern China.
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DOI：
10.1289/ehp.1103715
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发表时间：
2012-03
影响因子：
10.4
通讯作者：
Zhu T
中科院分区：
文献类型：
--
作者：
Tao Y;Huang W;Huang X;Zhong L;Lu SE;Li Y;Dai L;Zhang Y;Zhu T
背景和目标：流行病学研究将空气污染对健康的不利影响归因于空气污染;然而，关于环境氧化剂[臭氧（O3）和二氧化氮（NO2）]与死亡率之间的关系仍然存在争议，特别是在亚洲。我们进行了一个四个城市的时间序列研究，以探讨急性效应的O3和NO2在珠江三角洲（PRD）的中国南方，从2006年至2008年的数据。研究方法：我们使用广义线性模型和泊松回归，结合自然样条函数，分析急性死亡率与O3和NO2的相关性，并将PM10（直径≤ 10 μm的颗粒物）作为主要混杂因素。对个别城市和四个城市作为一个整体确定了影响估计数。我们根据O3的高暴露期和低暴露期对分析进行分层。结果：我们发现珠三角城市的环境氧化剂和每日死亡率之间存在一致的正相关。总体而言，在过去2天内，平均O3和NO2浓度增加10 μg/m3分别与总死亡率增加0.81% [95%置信区间（CI）：0.63%，1.00%]和1.95%（95% CI：1.62%，2.29%）相关，对心血管和呼吸系统死亡率的估计影响更强。调整PM10后，估计的O3对总死亡率和心血管死亡率的影响更强的暴露在高暴露月份（9月至11月），而呼吸死亡率与O3暴露在非高峰暴露月份。结论：我们的研究结果表明，在珠三角的O3和NO2的显着急性死亡率的影响，并加强进一步限制该地区的环境污染水平的理由。
Background and objectives: Epidemiologic studies have attributed adverse health effects to air pollution; however, controversy remains regarding the relationship between ambient oxidants [ozone (O3) and nitrogen dioxide (NO2)] and mortality, especially in Asia. We conducted a four-city time-series study to investigate acute effects of O3 and NO2 in the Pearl River Delta (PRD) of southern China, using data from 2006 through 2008. Methods: We used generalized linear models with Poisson regression incorporating natural spline functions to analyze acute mortality in association with O3 and NO2, with PM10 (particulate matter ≤ 10 μm in diameter) included as a major confounder. Effect estimates were determined for individual cities and for the four cities as a whole. We stratified the analysis according to high- and low- exposure periods for O3. Results: We found consistent positive associations between ambient oxidants and daily mortality across the PRD cities. Overall, 10-μg/m3 increases in average O3 and NO2 concentrations over the previous 2 days were associated with 0.81% [95% confidence interval (CI): 0.63%, 1.00%] and 1.95% (95% CI: 1.62%, 2.29%) increases in total mortality, respectively, with stronger estimated effects for cardiovascular and respiratory mortality. After adjusting for PM10, estimated effects of O3 on total and cardiovascular mortality were stronger for exposure during high-exposure months (September through November), whereas respiratory mortality was associated with O3 exposure during nonpeak exposure months only. Conclusions: Our findings suggest significant acute mortality effects of O3 and NO2 in the PRD and strengthen the rationale for further limiting the ambient pollution levels in the area.
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DOI：
10.3200/aeoh.59.5.228-236
发表时间：
2004-05-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Burnett, RT;Stieb, D;Dann, T
通讯作者：
Dann, T
在多站点时间序列研究中，在臭氧与死亡率之间的短期关联上，颗粒物的潜在混淆。
影响因子：
10.4
作者：
Bell, Michelle L.;Kim, Jee Young;Dominici, Francesca
通讯作者：
Dominici, Francesca
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
4.5
作者：
Chen, BH;Hong, CJ;Kan, HD
通讯作者：
Kan, HD
影响因子：
24.3
作者：
Braga, ALF;Zanobetti, A;Schwartz, J
通讯作者：
Schwartz, J