Highly porous phosphate-based glasses for controlled delivery of antibacterial Cu ions prepared via sol-gel chemistry.
Highly porous phosphate-based glasses for controlled delivery of antibacterial Cu ions prepared via sol-gel chemistry.
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介孔玻璃是一类很有前途的生物可吸收材料，其特点是具有高表面积和2 ~ 50 nm范围内的扩展孔隙度。这些特殊的性质使它们成为控制治疗离子和分子释放的理想材料。虽然介孔硅酸盐基玻璃（MSG）已经被广泛研究，但对介孔磷酸盐基玻璃（MPG）的研究却很少。在本研究中，采用溶胶-凝胶法和超分子模板相结合的方法合成了P2O5-CaO-Na2O体系中未掺杂和掺杂1、3和5 mol% Cu离子的MPG。采用非离子型三嵌段共聚物Pluronic P123作为模板剂。通过扫描电镜（SEM）、小角x射线散射（SAXS）和77 K氮气吸附-解吸分析对多孔结构进行了研究。利用固态31P魔角旋转核磁共振（31P MAS-NMR）和傅里叶变换红外光谱（FTIR）研究了磷酸盐网络的结构。通过电感耦合等离子体光学发射光谱（ICP-OES）在水中进行的降解研究表明，磷酸盐、Ca2+、Na+和Cu离子在7天的时间内以受控的方式释放。铜的可控释放与铜的负载成正比，为MPG注入了抗菌性能。在3天的时间内，观察到金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）细菌活力显著降低。大肠杆菌似乎比金黄色葡萄球菌对铜的抗菌作用更有抵抗力。该研究表明，铜掺杂MPG作为生物可吸收材料具有很大的潜力，可以控制抗菌离子的传递。介孔玻璃是一类很有前途的生物可吸收材料，其特点是具有高表面积和2 ~ 50 nm范围内的扩展孔隙度。
Mesoporous glasses are a promising class of bioresorbable biomaterials characterized by high surface area and extended porosity in the range of 2 to 50 nm. These peculiar properties make them ideal materials for the controlled release of therapeutic ions and molecules. Whilst mesoporous silicate-based glasses (MSG) have been widely investigated, much less work has been done on mesoporous phosphate-based glasses (MPG). In the present study, MPG in the P2O5–CaO–Na2O system, undoped and doped with 1, 3, and 5 mol% of Cu ions were synthesized via a combination of the sol–gel method and supramolecular templating. The non-ionic triblock copolymer Pluronic P123 was used as a templating agent. The porous structure was studied via a combination of Scanning Electron Microscopy (SEM), Small-Angle X-ray Scattering (SAXS), and N2 adsorption–desorption analysis at 77 K. The structure of the phosphate network was investigated via solid state 31P Magic Angle Spinning Nuclear Magnetic Resonance (31P MAS-NMR) and Fourier Transform Infrared (FTIR) spectroscopy. Degradation studies, performed in water via Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES), showed that phosphates, Ca2+, Na+ and Cu ions are released in a controlled manner over a 7 days period. The controlled release of Cu, proportional to the copper loading, imbues antibacterial properties to MPG. A significant statistical reduction of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacterial viability was observed over a 3 days period. E. coli appeared to be more resistant than S. aureus to the antibacterial effect of copper. This study shows that copper doped MPG have great potential as bioresorbable materials for controlled delivery of antibacterial ions. Mesoporous glasses are a promising class of bioresorbable biomaterials characterized by high surface area and extended porosity in the range of 2 to 50 nm.
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