Evidence for a subcircuit in medial entorhinal cortex representing elapsed time during immobility.
Evidence for a subcircuit in medial entorhinal cortex representing elapsed time during immobility.
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DOI：
10.1038/s41593-018-0252-8
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发表时间：
2018-11
影响因子：
25
通讯作者：
Dombeck DA
中科院分区：
文献类型：
--
作者：
Heys JG;Dombeck DA
The medial entorhinal cortex (MEC) is known to contain spatial encoding neurons that likely contribute to encoding spatial aspects of episodic memories. However, little is known about the role MEC plays in encoding temporal aspects of episodic memories, particularly during immobility. Here, using a virtual “Door-Stop” task for mice, we show MEC contains a representation of elapsed time during immobility, with individual time encoding neurons activated at a specific moment during the immobile interval. This representation consisted of a sequential activation of time encoding neurons and displayed variations in progression speed that correlated with variations in mouse timing behavior. Time and spatial encoding neurons were preferentially active during immobile and locomotion periods, respectively, were anatomically clustered with respect to each other and preferentially encoded the same variable across tasks or environments. These results suggest the existence of largely non-overlapping sub-circuits in MEC encoding time during immobility or space during locomotion.
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影响因子：
25
作者：
Dombeck, Daniel A.;Harvey, Christopher D.;Tian, Lin;Looger, Loren L.;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
16.2
作者：
Kraus, Benjamin J.;Brandon, Mark P.;Eichenbaum, Howard
通讯作者：
Eichenbaum, Howard
影响因子：
5.3
作者：
Arriaga, Moises;Han, Edward B.
通讯作者：
Han, Edward B.
影响因子：
64.8
作者：
Hainmueller T;Bartos M
通讯作者：
Bartos M
影响因子：
16.2
作者：
Kraus BJ;Robinson RJ 2nd;White JA;Eichenbaum H;Hasselmo ME
通讯作者：
Hasselmo ME