Interneuronal network model of theta-nested fast oscillations predicts differential effects of heterogeneity, gap junctions and short term depression for hyperpolarizing versus shunting inhibition.
Interneuronal network model of theta-nested fast oscillations predicts differential effects of heterogeneity, gap junctions and short term depression for hyperpolarizing versus shunting inhibition.
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DOI：
10.1371/journal.pcbi.1010094
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发表时间：
2022-12
影响因子：
4.3
通讯作者：
Canavier, Carmen C.
中科院分区：
文献类型：
--
作者：
Via, Guillem;Baravalle, Roman;Fernandez, Fernando R.;White, John A.;Canavier, Carmen C.
海马体中的θ波和γ波振荡被假定在记忆的编码与提取过程中发挥作用。最近有研究表明，内侧内嗅皮层中的一种内在快速γ波机制可通过θ波频率的光遗传刺激被募集，且在快速兴奋性突触传递受阻时仍能持续，这表明中间神经元网络γ波（ING）起到了一定作用。我们校准了一个由100个神经元组成的模型网络的被动和主动特性，以涵盖内侧内嗅皮层（mEC）中实验记录的小白蛋白阳性（PV+）神经元的被动特性范围以及频率/电流关系。还利用配对记录校准了化学突触和电突触的强度与概率，以及化学突触的动力学和短时程抑制（STD）。对于超极化抑制下的同步而言，那些对输入电阻有显著贡献的缝隙连接是必需的；这些网络展现出与在光遗传驱动的PV - ChR2小鼠实验中观察到的假定ING类似的θ波嵌套高频振荡。当模型中纳入短时程抑制时，网络在约200赫兹以上的频率会失去同步，因此对于足够强的驱动，快速振荡仅在θ波峰值之前被观察到。由于超极化突触提供了一种同步驱动，在存在异质性的情况下有助于维持稳定性，所以随着超极化抑制变弱，同步性会降低。相比之下，具有分流抑制的网络需要非生理水平的缝隙连接，才能在测量范围内利用传导延迟实现同步。
嵌套在较慢振荡中的快速振荡被假定通过在每个快速周期内对信息进行分块，从而在记忆的编码与提取中发挥作用；小白蛋白阳性抑制性中间神经元网络有助于产生快速振荡。我们的研究表明，在内嗅皮层中，这些神经元的内在动力学特性存在足够的异质性，电突触很可能是同步快速振荡所必需的。此外，同步性可能要求化学突触在这些振荡过程中具有相对于单个神经元动作电位阈值为负的反转电位。我们发现，支持快速振荡的慢相范围由短时程突触抑制控制。快速振荡在慢振荡中的精确锁相被假定为信息复用提供了可能。
Theta and gamma oscillations in the hippocampus have been hypothesized to play a role in the encoding and retrieval of memories. Recently, it was shown that an intrinsic fast gamma mechanism in medial entorhinal cortex can be recruited by optogenetic stimulation at theta frequencies, which can persist with fast excitatory synaptic transmission blocked, suggesting a contribution of interneuronal network gamma (ING). We calibrated the passive and active properties of a 100-neuron model network to capture the range of passive properties and frequency/current relationships of experimentally recorded PV+ neurons in the medial entorhinal cortex (mEC). The strength and probabilities of chemical and electrical synapses were also calibrated using paired recordings, as were the kinetics and short-term depression (STD) of the chemical synapses. Gap junctions that contribute a noticeable fraction of the input resistance were required for synchrony with hyperpolarizing inhibition; these networks exhibited theta-nested high frequency oscillations similar to the putative ING observed experimentally in the optogenetically-driven PV-ChR2 mice. With STD included in the model, the network desynchronized at frequencies above ~200 Hz, so for sufficiently strong drive, fast oscillations were only observed before the peak of the theta. Because hyperpolarizing synapses provide a synchronizing drive that contributes to robustness in the presence of heterogeneity, synchronization decreases as the hyperpolarizing inhibition becomes weaker. In contrast, networks with shunting inhibition required non-physiological levels of gap junctions to synchronize using conduction delays within the measured range. Fast oscillations nested within slower oscillations have been hypothesized to play a role in the encoding and retrieval of memories by chunking information within each fast cycle; networks of parvalbumin positive inhibitory interneurons contribute to the generation of fast oscillations. We show that, in the entorhinal cortex, the intrinsic dynamical properties of these neurons are sufficiently heterogeneous that electrical synapses are likely required to synchronize fast oscillations. Moreover, synchrony likely requires the chemical synapses to have a reversal potential that is negative relative to the action potential threshold of individual neurons during these oscillations. We show that the range of slow phases that support a fast oscillation is controlled by short term synaptic depression. The precise phase locking of the fast oscillation within the slow oscillations is hypothesized to allow for multiplexing of information.
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DOI：
10.1111/ejn.13831
发表时间：
2018-10
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Butler JL;Hay YA;Paulsen O
通讯作者：
Paulsen O
影响因子：
5.3
作者：
Atherton, JF;Bevan, MD
通讯作者：
Bevan, MD
影响因子：
3
作者：
Zariwala HA;Madisen L;Ahrens KF;Bernard A;Lein ES;Jones AR;Zeng H
通讯作者：
Zeng H
DOI：
10.1523/jneurosci.4122-11.2012
发表时间：
2012-01-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Belluscio MA;Mizuseki K;Schmidt R;Kempter R;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
4.3
作者：
Braun W;Memmesheimer RM
通讯作者：
Memmesheimer RM