Prostate cancer risk prediction based on complete prostate cancer family history.
Prostate cancer risk prediction based on complete prostate cancer family history.
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DOI：
10.1002/pros.22925
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发表时间：
2015-03-01
期刊：
影响因子：
2.8
通讯作者：
Albright, Lisa A. Cannon
中科院分区：
文献类型：
--
作者：
Albright, Frederick;Stephenson, Robert A.;Agarwal, Neeraj;Teerlink, Craig C.;Lowrance, William T.;Farnham, James M.;Albright, Lisa A. Cannon
前列腺癌（PC）的相对风险（RR）通常根据近亲的状态或任何受影响亲属的存在来估计。本研究使用广泛和特定的PC家族史提供RR估计。进行了一项基于人群的回顾性研究，以根据PC的完整家族史估计PC的RR。共分析了635,443名男性，所有男性都有祖先家谱数据。根据无PC家族史（一级、二级或三级亲属中无PC）男性的PC率估计值确定PC的RR。确定了各种星座的RR，例如，一至三级亲属的数量;命名（祖父，父亲，叔叔，堂兄弟，兄弟）;母亲，父亲关系和发病年龄。在分析的635，443名男性中，18，105人患有PC。一级RR范围为2.46（=1名一级亲属受累，CI = 2.39-2.53）至7.65（=4名一级亲属受累，CI = 6.28-9.23）。0例一级亲属受累的先证者的二级RR范围为1.51（≥1例二级亲属受累，CI = 1.47-1.56）至3.09（≥5例二级亲属受累，CI = 2.32-4.03）。一级亲属和二级亲属均未受累的三级RR范围为1.15（≥1名三级亲属受累，CI = 1.12-1.19）至1.50（≥5名三级亲属受累，CI = 1.35-1.66）。诊断时年龄越小，基于诊断时年龄的RR越高;例如，≥1名一级亲属在50岁之前诊断的RR = 5.54（CI = 1.12-1.19），>1名二级亲属在50岁之前诊断的RR = 1.78，CI = 1.33，2.33。相同的母亲与父亲的家族史的RR没有显着差异。使用近亲和远亲以及诊断时的年龄进行更完整的PC家族史，可获得更广泛的个体RR估计值，可能比从家族史汇总中估计的RR更准确。PC在二级甚至三级亲属中的存在显着增加了风险。母亲的家族史与父亲的家族史一样重要。基于先证者受影响亲属的完整星座的PC RR将允许患者和护理提供者做出更明智的筛查，监测和治疗决策。前列腺75：390-398，2015年。© 2014 Wiley Periodicals，Inc.
Prostate cancer (PC) relative risks (RRs) are typically estimated based on status of close relatives or presence of any affected relatives. This study provides RR estimates using extensive and specific PC family history. A retrospective population-based study was undertaken to estimate RRs for PC based on complete family history of PC. A total of 635,443 males, all with ancestral genealogy data, were analyzed. RRs for PC were determined based upon PC rates estimated from males with no PC family history (without PC in first, second, or third degree relatives). RRs were determined for a variety of constellations, for example, number of first through third degree relatives; named (grandfather, father, uncle, cousins, brothers); maternal, paternal relationships, and age of onset. In the 635,443 males analyzed, 18,105 had PC. First-degree RRs ranged from 2.46 (=1 first-degree relative affected, CI = 2.39–2.53) to 7.65 (=4 first-degree relatives affected, CI = 6.28–9.23). Second-degree RRs for probands with 0 affected first-degree relatives ranged from 1.51 (≥1 second-degree relative affected, CI = 1.47–1.56) to 3.09 (≥5 second-degree relatives affected, CI = 2.32–4.03). Third-degree RRs with 0 affected first- and 0 affected second-degree relatives ranged from 1.15 (≥1 affected third-degree relative, CI = 1.12–1.19) to 1.50 (≥5 affected third-degree relatives, CI = 1.35–1.66). RRs based on age at diagnosis were higher for earlier age at diagnoses; for example, RR = 5.54 for ≥1 first-degree relative diagnosed before age 50 years (CI = 1.12–1.19) and RR = 1.78 for >1 second-degree relative diagnosed before age 50 years, CI = 1.33, 2.33. RRs for equivalent maternal versus paternal family history were not significantly different. A more complete PC family history using close and distant relatives and age at diagnosis results in a wider range of estimates of individual RR that are potentially more accurate than RRs estimated from summary family history. The presence of PC in second- and even third-degree relatives contributes significantly to risk. Maternal family history is just as significant as paternal family history. PC RRs based on a proband's complete constellation of affected relatives will allow patients and care providers to make more informed screening, monitoring, and treatment decisions. Prostate 75:390–398, 2015. © 2014 Wiley Periodicals, Inc.
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影响因子：
30.8
作者：
Eeles, Rosalind A.;Al Olama, Ali Amin;Benlloch, Sara;Saunders, Edward J.;Leongamornlert, Daniel A.;Tymrakiewicz, Malgorzata;Ghoussaini, Maya;Luccarini, Craig;Dennis, Joe;Jugurnauth-Little, Sarah;Dadaev, Tokhir;Neal, David E.;Hamdy, Freddie C.;Donovan, Jenny L.;Muir, Ken;Giles, Graham G.;Severi, Gianluca;Wiklund, Fredrik;Gronberg, Henrik;Haiman, Christopher A.;Schumacher, Fredrick;Henderson, Brian E.;Le Marchand, Loic;Lindstrom, Sara;Kraft, Peter;Hunter, David J.;Gapstur, Susan;Chanock, Stephen J.;Berndt, Sonja I.;Albanes, Demetrius;Andriole, Gerald;Schleutker, Johanna;Weischer, Maren;Canzian, Federico;Riboli, Elio;Key, Tim J.;Travis, Ruth C.;Campa, Daniele;Ingles, Sue A.;John, Esther M.;Hayes, Richard B.;Pharoah, Paul D. P.;Pashayan, Nora;Khaw, Kay-Tee;Stanford, Janet L.;Ostrander, Elaine A.;Signorello, Lisa B.;Thibodeau, Stephen N.;Schaid, Dan;Maier, Christiane;Vogel, Walther;Kibel, Adam S.;Cybulski, Cezary;Lubhiski, Jan;Cannon-Albright, Lisa;Brenner, Hermann;Park, Jong Y.;Kaneva, Radka;Batra, Jyotsna;Spurdle, Amanda B.;Clements, Judith A.;Teixeira, Manuel R.;Dicks, Ed;Lee, Andrew;Dunning, Alison M.;Baynes, Caroline;Conroy, Don;Maranian, Melanie J.;Ahmed, Shahana;Govindasami, Koveela;Guy, Michelle;Wilkinson, Rosemary A.;Sawyer, Emma J.;Morgan, Angela;Dearnaley, David P.;Horwich, Alan;Huddart, Robert A.;Khoo, Vincent S.;Parker, Christopher C.;Van As, Nicholas J.;Woodhouse, Christopher J.;Thompson, Alan;Dudderidge, Tim;Ogden, Chris;Cooper, Colin S.;Lophatananon, Artitaya;Cox, Angela;Southey, Melissa C.;Hopper, John L.;English, Dallas R.;Aly, Markus;Adolfsson, Jan;Xu, Jiangfeng;Zheng, Siqun L.;Yeager, Meredith;Kaaks, Rudolf;Diver, W. Ryan;Gaudet, Mia M.;Stern, Mariana C.;Corral, Roman;Joshi, Amit D.;Shahabi, Ahva;Wahlfors, Tiina;Tammela, Teuvo L. J.;Auvinen, Anssi;Virtamo, Jarmo;Klarskov, Peter;Nordestgaard, Borge G.;Roder, M. Andreas;Nielsen, Sune F.;Bojesen, Stig E.;Siddiq, Afshan;FitzGerald, Liesel M.;Kolb, Suzanne;Kwon, Erika M.;Karyadi, Danielle M.;Blot, William J.;Zheng, Wei;Cai, Qiuyin;McDonnell, Shannon K.;Rinckleb, Antje E.;Drake, Bettina;Colditz, Graham;Wokolorczyk, Dominika;Stephenson, Robert A.;Teerlink, Craig;Muller, Heiko;Rothenbacher, Dietrich;Sellers, Thomas A.;Lin, Hui-Yi;Slavov, Chavdar;Mitev, Vanio;Lose, Felicity;Srinivasan, Srilakshmi;Maia, Sofia;Paulo, Paula;Lange, Ethan;Cooney, Kathleen A.;Antoniou, Antonis C.;Vincent, Daniel;Bacot, Francois;Tessier, Daniel C.;Kote-Jarai, Zsofia;Easton, Douglas F.
通讯作者：
Easton, Douglas F.
影响因子：
1.9
作者：
JORDE, LB
通讯作者：
JORDE, LB
影响因子：
4.5
作者：
Do, Chuong B.;Hinds, David A.;Eriksson, Nicholas
通讯作者：
Eriksson, Nicholas
影响因子：
23.4
作者：
Brandt, Andreas;Bermejo, Justo Lorenzo;Hemminki, Kari
通讯作者：
Hemminki, Kari
影响因子：
4
作者：
Roudgari, Hassan;Hemminki, Kari;Fallah, Mahdi
通讯作者：
Fallah, Mahdi