Acute Changes in Thyroid Hormone Levels among Thai Pesticide Sprayers.
Acute Changes in Thyroid Hormone Levels among Thai Pesticide Sprayers.
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DOI：
10.3390/toxics9010016
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发表时间：
2021-01-19
期刊：
影响因子：
4.6
通讯作者：
Woskie S
中科院分区：
文献类型：
--
作者：
Kongtip P;Nankongnab N;Pundee R;Kallayanatham N;Pengpumkiat S;Chungcharoen J;Phommalachai C;Konthonbut P;Choochouy N;Sowanthip P;Khangkhun P;Yimsabai J;Woskie S
本研究的目的是调查泰国农民急性农药暴露与甲状腺激素急性变化的关系。我们招募了78名农民，他们计划喷洒杀虫剂（毒死蜱和/或氯氰菊酯）或除草剂（百草枯和/或草甘膦）。在喷洒前一天，农民收集了他们的第一次晨尿，然后去采血。在喷雾日，在喷雾事件结束时收集尿液样本，并使用问卷进行访谈。第二天早上，收集第一个早晨的尿液和血液样本。分析血液样本的甲状腺激素。分析尿样中喷洒的杀虫剂的代谢物。结果表明，随着毒死蜱代谢产物尿中含量的增加，施药后第2天，甲状腺激素、游离三碘甲腺原氨酸（FT 3）和总三碘甲腺原氨酸（T3）含量均显著降低。总甲状腺素（T4）显着增加，氯氰菊酯代谢物增加喷洒后的一天。随着尿液中草甘膦水平的增加，T4显着增加;然而，随着喷洒后第二天尿液中百草枯水平的增加，FT 3和T3显着下降。这些研究结果表明，急性暴露于农药毒死蜱、氯氰菊酯、百草枯和草甘膦可对下丘脑-垂体-甲状腺（HPT）轴产生急性影响，从而急剧改变甲状腺激素水平。
The objective of this study was to investigate the relationship of acute pesticide exposures and acute changes in thyroid hormones among Thai farmers. We recruited 78 farmers, who were scheduled to spray insecticides (chlorpyrifos and/or cypermethrin) or herbicides (paraquat and/or glyphosate). On the day before spraying, farmers collected their first morning void urine and went for blood collection. On the spray day, urine samples were collected at end of the spraying event and they were interviewed with questionnaires. The next morning, the first morning void urine and blood samples were collected. Blood samples were analyzed for thyroid hormones. Urine samples were analyzed for the metabolites of the pesticide sprayed. The results showed that the thyroid hormones, free triiodothyronine (FT3) and total triiodothyronine (T3) were significantly reduced as urinary chlorpyrifos metabolite increased the day after spraying. Total thyroxine (T4) significantly increased as cypermethrin metabolites increased the day after spraying. T4 significantly increased as urinary glyphosate levels increased; however, FT3 and T3 decreased significantly as urinary paraquat levels increased the day after spraying. These findings suggest that acute exposures to the pesticides chlorpyrifos, cypermethrin, paraquat and glyphosate can produce acute effects on the hypothalamic–pituitary–thyroid (HPT) axis, acutely altering thyroid hormone levels.
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DOI：
10.1080/10807039.2020.1797471
发表时间：
2021
期刊：
Human and ecological risk assessment : HERA
影响因子：
--
作者：
Bootsikeaw S;Kongtip P;Nankongnab N;Chantanakul S;Sujirarat D;Mahaboonpeeti R;Khangkhun P;Woskie S
通讯作者：
Woskie S
DOI：
10.1016/j.ijheh.2018.09.004
发表时间：
2019-03-01
影响因子：
6
作者：
Connolly, Alison;Jones, Kate;Coggins, Marie A.
通讯作者：
Coggins, Marie A.
DOI：
10.1097/jom.0b013e31829b290b
发表时间：
2013-10
影响因子：
3.2
作者：
Goldner WS;Sandler DP;Yu F;Shostrom V;Hoppin JA;Kamel F;LeVan TD
通讯作者：
LeVan TD
影响因子：
9.7
作者：
HEINONENTANSKI, H
通讯作者：
HEINONENTANSKI, H
针对农民及其家人的草甘膦生物监测：农场家庭暴露研究的结果。
影响因子：
10.4
作者：
Acquavella, JF;Alexander, BH;Mandel, JS;Gustin, C;Baker, B;Chapman, P;Bleeke, M
通讯作者：
Bleeke, M