Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus.
Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus.
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边缘区/CD1d(hi) B 细胞在小鼠狼疮模型中的滤泡内位置与自身免疫病理学有关。
DOI：
10.1038/labinvest.2008.62
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发表时间：
2008-09
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
作者：
边缘区（MZ） B细胞含有大量的自身反应性克隆，该区室的扩张与自身免疫有关。mzb细胞还能有效地将血源性抗原运送到卵泡，在那里它们激活T细胞并分化成浆细胞。使用B6.NZM2410.Sle1.Sle2。Sle3 （B6.TC）狼疮模型，我们发现IgM+ CD1dhi/MZ b细胞区室扩大，并且大量存在于滤泡内。与外周b细胞亚群分布及其激活状态相反，B6的小泡内位置。TC IgM+ CD1dhi/MZ B细胞依赖于骨髓和基质源性因子。在造成这种小泡内定位的因素中，我们已经确定B6对CXCL13的反应增加。B6间质细胞VCAM-1表达降低。TC MZ。然而，在B6中观察到MZ巨噬细胞数量减少。TC MZs与IgM+ cd1hi / b细胞位置无关。B7-2缺失恢复了B6中IgM+ CD1dhi/MZ b细胞滤泡排斥，但B7-1缺失不恢复。它与对dsDNA的耐受性和自身免疫病理的显著减少相关。这些结果表明卵泡排斥IgM+ CD1dhi/MZ B细胞是一个重要的B细胞耐受机制，B7-2信号通路参与了突破这个耐受检查点。
Marginal zone (MZ) B cells contain a large number of autoreactive clones and the expansion of this compartment has been associated with autoimmunity. MZ B cells also efficiently transport blood-borne antigen to the follicles where they activate T cells and differentiate into plasma cells. Using the B6.NZM2410.Sle1.Sle2.Sle3 (B6.TC) model of lupus, we show that the IgM+ CD1dhi/MZ B-cell compartment is expanded, and a large number of them reside inside the follicles. Contrary to the peripheral B-cell subset distribution and their activation status, the intrafollicular location of B6.TC IgM+ CD1dhi/MZ B cells depends on both bone marrow- and stromal-derived factors. Among the factors responsible for this intrafollicular location, we have identified an increased response to CXCL13 by B6.TC MZ B cells and a decreased expression of VCAM-1 on stromal cells in the B6.TC MZ. However, the reduced number of MZ macrophages observed in B6.TC MZs was independent of the IgM+ CD1dhi/B-cell location. B7-2 but not B7-1 deficiency restored IgM+ CD1dhi/MZ B-cell follicular exclusion in B6.TC mice, and it correlated with tolerance to dsDNA and a significant reduction of autoimmune pathology. These results suggest that follicular exclusion of IgM+ CD1dhi/MZ B cells is an important B-cell tolerance mechanism, and that B7-2 signaling is involved in breaching this tolerance checkpoint.
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影响因子：
4.4
作者：
Gunn, Kathryn E.;Brewer, Joseph W.
通讯作者：
Brewer, Joseph W.
淋巴细胞进入脾白髓的整合素依赖性。
DOI：
10.1084/jem.20021569
发表时间：
2003-02-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lo CG;Lu TT;Cyster JG
通讯作者：
Cyster JG
DOI：
10.1016/s0074-7696(06)50005-1
发表时间：
2006
期刊：
International review of cytology
影响因子：
--
作者：
Kraal G;Mebius R
通讯作者：
Mebius R
DOI：
10.1084/jem.20011453
发表时间：
2002-01-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Li Y;Li H;Weigert M
通讯作者：
Weigert M
影响因子：
30.5
作者：
Cinamon, Guy;Zachariah, Marcus A.;Cyster, Jason G.
通讯作者：
Cyster, Jason G.