The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat.
The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat.
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DOI：
10.1186/1423-0127-19-103
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发表时间：
2012-12-15
影响因子：
11
通讯作者：
Deuchars SA
中科院分区：
文献类型：
--
作者：
Lall VK;Dutschmann M;Deuchars J;Deuchars SA
甲氟喹是一种抗疟疾药物，可能会产生神经副作用。本研究使用大鼠动脉灌流的工作心脏脑干制剂(WHBP)，研究甲氟喹(MF)如何影响自主神经和呼吸系统的中枢神经控制。记录大鼠胸交感神经链和膈神经的神经活动，同时监测动脉灌流、去大脑大鼠的心率和灌流压。在灌流液中加入1μM的MF，以检测其对基线参数以及压力感受器和化学感受器反射的影响。MF引起明显的阿托品抵抗、心动过缓和膈神经放电频率增加。灌流液中加入0.03%氰化钠0.1ml可显著减弱化学感受器介导的交感兴奋。此外，MF显着降低了化学感受器诱发的心动过缓后恢复静息心率的速度。与对照组相比，在化学感受器刺激期间，MF还引起呼吸频率的增加和呼吸相关交感神经放电的减弱。然而，MF并没有显著改变压力感受器反射的敏感性。这些研究表明，在WHBP中，MF导致自主神经和呼吸控制的深刻变化。讨论了这些作用可能是通过对控制交感神经流出的中枢神经元中含有缝隙连接的连接蛋白36的作用来介导的。
Mefloquine is an anti-malarial drug that can have neurological side effects. This study examines how mefloquine (MF) influences central nervous control of autonomic and respiratory systems using the arterially perfused working heart brainstem preparation (WHBP) of the rat. Recordings of nerve activity were made from the thoracic sympathetic chain and phrenic nerve, while heart rate (HR) and perfusion pressure were also monitored in the arterially perfused, decerebrate, rat WHBP. MF was added to the perfusate at 1 μM to examine its effects on baseline parameters as well as baroreceptor and chemoreceptor reflexes. MF caused a significant, atropine resistant, bradycardia and increased phrenic nerve discharge frequency. Chemoreceptor mediated sympathoexcitation (elicited by addition of 0.1 ml of 0.03% sodium cyanide to the aortic cannula) was significantly attenuated by the application of MF to the perfusate. Furthermore MF significantly decreased rate of return to resting HR following chemoreceptor induced bradycardia. An increase in respiratory frequency and attenuated respiratory-related sympathetic nerve discharge during chemoreceptor stimulation was also elicited with MF compared to control. However, MF did not significantly alter baroreceptor reflex sensitivity. These studies indicate that in the WHBP, MF causes profound alterations in autonomic and respiratory control. The possibility that these effects may be mediated through actions on connexin 36 containing gap junctions in central neurones controlling sympathetic nervous outflow is discussed.
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影响因子：
3.3
作者：
Pierce, M. L.;Deuchars, J.;Deuchars, S. A.
通讯作者：
Deuchars, S. A.
成年大鼠的交感神经前和体细胞神经元中连接性的连接蛋白36的免疫组织化学检测。
影响因子：
2.7
作者：
Marina, Nephtali;Becker, David L.;Gilbey, Michael P.
通讯作者：
Gilbey, Michael P.
影响因子：
7.3
作者：
Nolan, MF;Gibson, IC;Logan, SD
通讯作者：
Logan, SD
影响因子：
6.7
作者：
Simpson, JA;Price, R;White, NJ
通讯作者：
White, NJ
DOI：
10.1016/s0034-5687(01)00299-7
发表时间：
2001-12-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Solomon, IC;Halat, TJ;O'Neal, MH
通讯作者：
O'Neal, MH