Chloride and organic osmolytes: a hybrid strategy to cope with elevated salinities by the moderately halophilic, chloride-dependent bacterium Halobacillus halophilus.
Chloride and organic osmolytes: a hybrid strategy to cope with elevated salinities by the moderately halophilic, chloride-dependent bacterium Halobacillus halophilus.
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氯化物和有机渗透剂：中度嗜盐、氯化物依赖性细菌嗜盐杆菌应对盐度升高的混合策略
DOI：
10.1111/j.1462-2920.2012.02770.x
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发表时间：
2012
影响因子：
5.1
通讯作者：
Oesterhelt
中科院分区：
文献类型：
--
作者：
Pfeiffer;Schuster;Müller;Oesterhelt
Salt acclimation in moderately halophilic bacteria is the result of action of a grand interplay orchestrated by signals perceived from the environment. To elucidate the cellular players involved in sensing and responding to changing salinities we have determined the genome sequence ofHalobacillus halophilus, a Gram‐positive moderate halophilic bacterium that has a strict requirement for the anion chloride.Halobacillus halophilussynthesizes a multitude of different compatible solutes and switches its osmolyte strategy with the external salinity and growth phase. Based on the emerging genome sequence, the compatible solutes glutamate, glutamine, proline and ectoine have already been experimentally studied. The biosynthetic routes for acetyl ornithine and acetyl lysine are also delineated from the genome sequence.Halobacillus halophilusis nutritionally very versatile and most compatible solutes cannot only be produced but also used as carbon and energy sources. The genome sequence unravelled isogenes for many pathways indicating a fine regulation of metabolism.Halobacillus halophilusis unique in integrating the concept of compatible solutes with the second fundamental principle to cope with salt stress, the accumulation of molar concentrations of salt (Cl‐) in the cytoplasm. Extremely halophilic bacteria/archaea, which exclusively rely on the salt‐in strategy, have a high percentage of acidic proteins compared with non‐halophiles with a low percentage.Halobacillus halophilushas an intermediate position which is consistent with its ability to integrate both principles.
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