Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development.
Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development.
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DOI：
10.1371/journal.pone.0033828
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Oland LA
中科院分区：
文献类型：
--
作者：
Gibson NJ;Tolbert LP;Oland LA
天蛾成虫嗅觉系统的发育依赖于从外周生长的嗅觉受体神经元（ORN）轴突和中枢神经胶质细胞之间的相互作用。早期到达的ORN轴突诱导胶质细胞的一个子集增殖和迁移，形成轴突分选区，其中稍后到达的ORN轴突将改变它们的轴突邻居并改变它们的生长方向，以便与类似的轴突一起行进到它们在嗅（触角）叶中的目标区域。这些新成束的轴突束将终止于原肾小球，其形成诱导其他胶质细胞迁移到它们周围。神经胶质细胞不迁移，除非ORN轴突存在，轴突不能成束和正确的目标没有足够的神经胶质细胞，和原肾小球不能维持没有神经胶质包围。我们以前已经表明，表皮生长因子受体和IgCAMs神经胶质细胞和Fasciclin II在ORN对神经胶质细胞的反应中发挥作用。在目前的工作中，我们提出了证据的重要性，胶质细胞成纤维细胞生长因子受体在胶质细胞的迁移，增殖和生存在这一发展途径。我们还报告了ORN轴突和嗅（触角叶）神经元树突的生长模式的变化，神经胶质FGFR激活的阻滞后，这表明，神经胶质FGFR激活是重要的神经元和神经胶质细胞之间的相互沟通。
Development of the adult olfactory system of the moth Manduca sexta depends on reciprocal interactions between olfactory receptor neuron (ORN) axons growing in from the periphery and centrally-derived glial cells. Early-arriving ORN axons induce a subset of glial cells to proliferate and migrate to form an axon-sorting zone, in which later-arriving ORN axons will change their axonal neighbors and change their direction of outgrowth in order to travel with like axons to their target areas in the olfactory (antennal) lobe. These newly fasciculated axon bundles will terminate in protoglomeruli, the formation of which induces other glial cells to migrate to surround them. Glial cells do not migrate unless ORN axons are present, axons fail to fasciculate and target correctly without sufficient glial cells, and protoglomeruli are not maintained without a glial surround. We have shown previously that Epidermal Growth Factor receptors and the IgCAMs Neuroglian and Fasciclin II play a role in the ORN responses to glial cells. In the present work, we present evidence for the importance of glial Fibroblast Growth Factor receptors in glial migration, proliferation, and survival in this developing pathway. We also report changes in growth patterns of ORN axons and of the dendrites of olfactory (antennal lobe) neurons following blockade of glial FGFR activation that suggest that glial FGFR activation is important in reciprocal communication between neurons and glial cells.
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