The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease.
The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease.
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脑小血管疾病中类淋巴系统功能障碍与认知障碍之间的关联
DOI：
10.3389/fnagi.2022.916633
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
脑小血管病（CSVD）患者认知功能障碍的机制尚不清楚。胶质淋巴系统功能障碍，这已被证明会影响认知障碍，可以通过沿着血管周围空间的扩散张量图像分析（ALPS指数）进行评估。我们探讨了CSVD的认知功能障碍是否与胶质淋巴清除功能障碍有关。在这项研究中，133例CSVD患者入组，并接受神经心理测试电池以及磁共振成像（MRI）。然后将他们分为CSVD伴认知障碍（CSVD-CI）组和认知正常CSVD（CSVD-CN）组。还评估了ALPS指数和4种CSVD标志物[白色病变（WML）、脑微出血（CMB）、腔隙和血管周围间隙（PVS）]。单因素分析显示，CSVD-CN组（n = 50）和CSVD-CI组（n = 83）之间的ALPS指数有显著差异（p < 0.001）。在调整了6个常见风险因素（年龄、教育、高血压、糖尿病、吸烟和酗酒）以及CSVD标志物后，这种差异仍然显著（95%CI < 0.001-0.133）。在调整上述六个危险因素或CSVD标志物后，ALPS指数与整体认知功能、执行功能、注意力功能和记忆力独立线性相关。我们的研究结果表明，胶质淋巴系统损害是独立相关的CSVD患者的认知功能障碍。
The mechanism of cognitive impairment in patients with cerebral small vessel disease (CSVD) remains unknown. The glymphatic system dysfunction, which has been demonstrated to influence cognitive impairment, can be evaluated by diffusion tensor image analysis along the perivascular space (ALPS index). We explored whether cognitive impairment in CSVD is associated with glymphatic clearance dysfunction. In this study, 133 patients with CSVD were enrolled and underwent neuropsychological test batteries as well as magnetic resonance imaging (MRI). They were then categorized into a CSVD with cognitive impairment (CSVD-CI) group and a cognitively normal CSVD (CSVD-CN) group. The ALPS index and four CSVD markers [white matter lesions (WMLs), cerebral microbleeds (CMBs), lacunes, and perivascular spaces (PVSs)] were also assessed. Univariate analysis showed that the ALPS index was significantly different between the CSVD-CN (n = 50) and CSVD-CI groups (n = 83) (p < 0.001). This difference remained significant (95% CI < 0.001–0.133) after adjusting for six common risk factors (age, education, hypertension, diabetes, smoking, and alcohol abuse) as well as CSVD markers. The ALPS index was independently linearly correlated with global cognitive function, executive function, attention function, and memory after adjusting for the aforementioned six risk factors or CSVD markers. Our results suggest that glymphatic system impairment is independently related to cognitive impairment in patients with CSVD.
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影响因子：
16.6
作者：
Hablitz, Lauren M.;Pla, Virginia;Nedergaard, Maiken
通讯作者：
Nedergaard, Maiken
影响因子：
--
作者：
Chen HL;Chen PC;Lu CH;Tsai NW;Yu CC;Chou KH;Lai YR;Taoka T;Lin WC
通讯作者：
Lin WC
DOI：
10.1002/alz.12221
发表时间：
2021-04
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Hamilton OKL;Backhouse EV;Janssen E;Jochems ACC;Maher C;Ritakari TE;Stevenson AJ;Xia L;Deary IJ;Wardlaw JM
通讯作者：
Wardlaw JM
DOI：
10.1126/science.abb8739
发表时间：
2020-10-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Nedergaard M;Goldman SA
通讯作者：
Goldman SA
DOI：
10.1159/000375153
发表时间：
2015
期刊：
Cerebrovascular diseases (Basel, Switzerland)
影响因子：
--
作者：
Potter GM;Chappell FM;Morris Z;Wardlaw JM
通讯作者：
Wardlaw JM